Increased erythrocyte aggregation in diabetes mellitus and its relationship to glycosylated haemoglobin and retinopathy

M. Satoh; K. Imaizumi; T. Bessho; T. Shiga

doi:10.1007/BF00290387

Increased erythrocyte aggregation in diabetes mellitus and its relationship to glycosylated haemoglobin and retinopathy

M. Satoh^*, K. Imaizumi, T. Bessho, T. Shiga

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The velocity of erythrocyte aggregation in vitro was determined in 15 non-diabetic and 28 Type 1 (insulin-dependent) diabetic subjects, in autologous plasma under uniform shear flow using a rheoscope combined with a television image analyzer and a computer. In the diabetic subjects, the velocity of aggregation showed a significant correlation with the haemoglobin A₁ level, and was significantly increased in the proliferative retinopathy group. An alteration of plasma protein composition in the diabetic subjects (increase of Ø- and α₂-fractions) also influenced erythrocyte aggregation, being related to the haemoglobin A₁ level. The percentage of the Ø-fraction and a parameter, (α₂+φ)/albumin, defined by plasma electrophoresis, showed a strong correlation with the velocity of aggregation.

Original language	English
Pages (from-to)	517-521
Number of pages	5
Journal	Diabetologia
Volume	27
Issue number	5
DOIs	https://doi.org/10.1007/BF00290387
Publication status	Published - 1984 Nov
Externally published	Yes

Keywords

blood rheology
Diabetes
erythrocyte aggregation
glycosylated haemoglobin
plasma proteins
retinopathy

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00290387

Cite this

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abstract = "The velocity of erythrocyte aggregation in vitro was determined in 15 non-diabetic and 28 Type 1 (insulin-dependent) diabetic subjects, in autologous plasma under uniform shear flow using a rheoscope combined with a television image analyzer and a computer. In the diabetic subjects, the velocity of aggregation showed a significant correlation with the haemoglobin A1 level, and was significantly increased in the proliferative retinopathy group. An alteration of plasma protein composition in the diabetic subjects (increase of {\O}- and α2-fractions) also influenced erythrocyte aggregation, being related to the haemoglobin A1 level. The percentage of the {\O}-fraction and a parameter, (α2+φ)/albumin, defined by plasma electrophoresis, showed a strong correlation with the velocity of aggregation.",

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AU - Satoh, M.

AU - Imaizumi, K.

AU - Bessho, T.

AU - Shiga, T.

PY - 1984/11

Y1 - 1984/11

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AB - The velocity of erythrocyte aggregation in vitro was determined in 15 non-diabetic and 28 Type 1 (insulin-dependent) diabetic subjects, in autologous plasma under uniform shear flow using a rheoscope combined with a television image analyzer and a computer. In the diabetic subjects, the velocity of aggregation showed a significant correlation with the haemoglobin A1 level, and was significantly increased in the proliferative retinopathy group. An alteration of plasma protein composition in the diabetic subjects (increase of Ø- and α2-fractions) also influenced erythrocyte aggregation, being related to the haemoglobin A1 level. The percentage of the Ø-fraction and a parameter, (α2+φ)/albumin, defined by plasma electrophoresis, showed a strong correlation with the velocity of aggregation.

KW - blood rheology

KW - Diabetes

KW - erythrocyte aggregation

KW - glycosylated haemoglobin

KW - plasma proteins

KW - retinopathy

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Increased erythrocyte aggregation in diabetes mellitus and its relationship to glycosylated haemoglobin and retinopathy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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