Induction of Cell Death in Mesothelioma Cells by Magnetite Nanoparticles

Shofu Matsuda, Airi Hitsuji, Takuya Nakanishi, Hong Zhang, Akane Tanaka, Hiroshi Matsuda, Tetsuya Osaka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Nanoparticle uptake and cell death following addition of magnetite nanoparticles (MNPs) with a diameter of ∼10 nm were evaluated in three histological types of human mesothelioma cells, NCI-H28 (epithelioid), NCI-H2052 (sarcomatoid), and MSTO-211H (biphasic) cells, and human breast cancer MCF-7 cells. Dose-dependent cell death was observed in MSTO-211H cells but not in MCF-7 cells, although cellular uptake of MNPs was observed in both cell types. Mesothelioma NCI-H28 and NCI-H2052 cells showed behavior more similar to that of breast cancer MCF-7 cells than that of mesothelioma MSTO-211H cells. DNA fragmentation and microarray analyses suggested that MNPs induced transforming growth factor β2 related apoptosis in MSTO-211H cells. On the other hand, the viability of human mesothelioma cells containing MNPs with a diameter of ∼40 nm was investigated after exposure to an alternating magnetic field. Temperature increase under the alternating magnetic field and high rates of cell death were observed in all three histological types of human mesothelioma.

Original languageEnglish
Pages (from-to)632-638
Number of pages7
JournalACS Biomaterials Science and Engineering
Issue number8
Publication statusPublished - 2015 Dec 14


  • cytotoxicity
  • magnetite nanoparticles
  • mesothelioma
  • uptake

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Induction of Cell Death in Mesothelioma Cells by Magnetite Nanoparticles'. Together they form a unique fingerprint.

Cite this