Abstract
Mitochondria play a central role in energy production but also are the main cellular source of reactive oxygen species (ROS). It is widely believed that aging is related to the accumulation of oxidative molecular damage due to ROS. Aging also induces a decrease in muscle function. Recent studies indicate that caloric restriction and physical exercise suppress the decrease in muscle function though the maintaining quality of mitochondria. This review provides the current understanding of the influence of caloric restriction and exercise on mitochondrial quality control in skeletal muscle.
| Original language | English |
|---|---|
| Pages (from-to) | 389-396 |
| Number of pages | 8 |
| Journal | japanese journal of physical fitness and sports medicine |
| Volume | 64 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 |
| Externally published | Yes |
Keywords
- Aging
- Mitochondrial biogenesis
- Mitophagy
- Muscle health
- Oxidative stress
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation