TY - JOUR
T1 - Inhibition effect of aggregation of phospholipid vesicles by incorporation of glycolipids
AU - Takeoka, Shinji
AU - Sakai, Hiromi
AU - Ohno, Hiroyuki
AU - Yoshimura, Kiyoshi
AU - Tsuchida, Eishun
N1 - Funding Information:
This work was partially supported by a Grant-in-Aid from the Ministry of Education, Science, and Culture, Japan.
PY - 1992/9
Y1 - 1992/9
N2 - Oligosaccharide fatty acid esters (glycolipids) [GkmCn; k, number of α-1,4-bound glucose unit (G) (k = 2, 5, 7); m, number of fatty acid (C) (m = 1, 2); and n, number of methylene unit (n = 12, 16, 22)] were synthesized. Aggregation of unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) below a gel-to-liquid crystalline phase transition temperature (43°C) were inhibited by incorporation of glycolipids into bilayer membrane and G51C16 was clarified to be the most effective structure. The complete inhibition by G51C16 could be achieved by the addition of 2 mol% of G51C16 to less than 0.5 wt% of DPPC liposomes at room temperature. This glycolipid also restricts the aggregation of liposomes induced by polyethyleneglycol or polysaccharide and improves the packing of lipids in the bilayer membrane.
AB - Oligosaccharide fatty acid esters (glycolipids) [GkmCn; k, number of α-1,4-bound glucose unit (G) (k = 2, 5, 7); m, number of fatty acid (C) (m = 1, 2); and n, number of methylene unit (n = 12, 16, 22)] were synthesized. Aggregation of unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) below a gel-to-liquid crystalline phase transition temperature (43°C) were inhibited by incorporation of glycolipids into bilayer membrane and G51C16 was clarified to be the most effective structure. The complete inhibition by G51C16 could be achieved by the addition of 2 mol% of G51C16 to less than 0.5 wt% of DPPC liposomes at room temperature. This glycolipid also restricts the aggregation of liposomes induced by polyethyleneglycol or polysaccharide and improves the packing of lipids in the bilayer membrane.
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U2 - 10.1016/0021-9797(92)90037-M
DO - 10.1016/0021-9797(92)90037-M
M3 - Article
AN - SCOPUS:0141492528
SN - 0021-9797
VL - 152
SP - 351
EP - 358
JO - Journal of Colloid And Interface Science
JF - Journal of Colloid And Interface Science
IS - 2
ER -