TY - JOUR
T1 - Inhibitory and excitatory effects of histamine on suprachiasmatic neurons in rat hypothalamic slice preparation
AU - Yuh Liou, Shyh
AU - Shibata, Shigenobu
AU - Yamakawa, Katsunori
AU - Ueki, Showa
N1 - Funding Information:
This work was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture, Japan.
PY - 1983/10/31
Y1 - 1983/10/31
N2 - The effects of histamine (HA) and serotonin (5-HT) on single neurons of the suprachiasmatic nucleus (SCN) in hypothalamic slices were investigated by iontophoretic application. Sixty-two of 181 cells were inhibited by HA, whereas 30 were excited. Forty-nine of 163 cells were inhibited by 5-HT, whereas 9 were excited. Pyrilamine, an H1-antagonist, slightly (2/7), and cimetidine, an H2-antagonist, strongly (10/13) antagonized the inhibitory effect of HA. The excitatory effect of HA was not antagonized by cimetidine (0/4), but was perfectly antagonized by pyrilamine (5/5). The present results suggest that HA and 5-HT play mainly an inhibitory role in the SCN neuronal activity, and that inhibition and excitation induced by HA may be mediated by H2- and H1-receptors, respectively.
AB - The effects of histamine (HA) and serotonin (5-HT) on single neurons of the suprachiasmatic nucleus (SCN) in hypothalamic slices were investigated by iontophoretic application. Sixty-two of 181 cells were inhibited by HA, whereas 30 were excited. Forty-nine of 163 cells were inhibited by 5-HT, whereas 9 were excited. Pyrilamine, an H1-antagonist, slightly (2/7), and cimetidine, an H2-antagonist, strongly (10/13) antagonized the inhibitory effect of HA. The excitatory effect of HA was not antagonized by cimetidine (0/4), but was perfectly antagonized by pyrilamine (5/5). The present results suggest that HA and 5-HT play mainly an inhibitory role in the SCN neuronal activity, and that inhibition and excitation induced by HA may be mediated by H2- and H1-receptors, respectively.
KW - histamine
KW - rat hypothalamic slice
KW - serotonin
KW - single units
KW - suprachiasmatic nucleus
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U2 - 10.1016/0304-3940(83)90231-8
DO - 10.1016/0304-3940(83)90231-8
M3 - Article
C2 - 6646509
AN - SCOPUS:0021074294
SN - 0304-3940
VL - 41
SP - 109
EP - 113
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -