TY - JOUR
T1 - Inhibitory effect of crude-drug extracts on the degranulation of mast cells (RBL-2H3)
AU - Asano, Mariko
AU - Dohi, Megumi
AU - Yazawa, Kazunaga
AU - Kometani, Takashi
AU - Takahashi, Kyoko
PY - 2011
Y1 - 2011
N2 - The prevalence of type I allergies, including food allergies and atopic dermatitis is increasing worldwide. Chinese medicines and crude drugs have been used for treatment of these allergies ; however, the mechanisms of the treatment efects remain unclear. In the present study, we investigated the inhibitory efects of crude drugs on the degranulation of mast cells using the crude hot-water extracts of 83 types of crude drugs. Among the crude drugs, extracts from Ni-kei, fun-bo-i, ku-se-ki and on-ji most significantly inhibited the release of b-hexosaminidase in RBL-2H3 cells, with IC50 values of 215.7, 79.1, 187.6 and 288.1 ug/ml, respectively.
AB - The prevalence of type I allergies, including food allergies and atopic dermatitis is increasing worldwide. Chinese medicines and crude drugs have been used for treatment of these allergies ; however, the mechanisms of the treatment efects remain unclear. In the present study, we investigated the inhibitory efects of crude drugs on the degranulation of mast cells using the crude hot-water extracts of 83 types of crude drugs. Among the crude drugs, extracts from Ni-kei, fun-bo-i, ku-se-ki and on-ji most significantly inhibited the release of b-hexosaminidase in RBL-2H3 cells, with IC50 values of 215.7, 79.1, 187.6 and 288.1 ug/ml, respectively.
KW - Crude drug
KW - Degranulation
KW - Typel allergy
UR - http://www.scopus.com/inward/record.url?scp=80755127249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80755127249&partnerID=8YFLogxK
U2 - 10.3136/nskkk.58.330
DO - 10.3136/nskkk.58.330
M3 - Article
AN - SCOPUS:80755127249
SN - 1341-027X
VL - 58
SP - 330
EP - 334
JO - Nippon Shokuhin Kagaku Kogaku Kaishi
JF - Nippon Shokuhin Kagaku Kogaku Kaishi
IS - 7
ER -