Inhibitory effects of pasuchaca (Geranium dielsiaum) extract on α-glucosidase in mouse

Mariko Karato, Kohji Yamaguchi, Shin Takei, Takao Kino, Kazunaga Yazawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activity revealed that PsEx strongly inhibited mouse small intestine maltase activity. Taken together, these results suggest that the inhibitory effect of PsEx on α-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.

Original languageEnglish
Pages (from-to)1482-1484
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number6
Publication statusPublished - 2006
Externally publishedYes


  • α-glucosidase
  • Diabetes
  • Inhibitor
  • Pasuchaca

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science


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