Inhibitory effects of pasuchaca (Geranium dielsiaum) extract on α-glucosidase in mouse

Mariko Karato; Kohji Yamaguchi; Shin Takei; Takao Kino; Kazunaga Yazawa

doi:10.1271/bbb.50420

Inhibitory effects of pasuchaca (Geranium dielsiaum) extract on α-glucosidase in mouse

Mariko Karato, Kohji Yamaguchi, Shin Takei, Takao Kino, Kazunaga Yazawa^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activity revealed that PsEx strongly inhibited mouse small intestine maltase activity. Taken together, these results suggest that the inhibitory effect of PsEx on α-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.

Original language	English
Pages (from-to)	1482-1484
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	70
Issue number	6
DOIs	https://doi.org/10.1271/bbb.50420
Publication status	Published - 2006
Externally published	Yes

Keywords

α-glucosidase
Diabetes
Inhibitor
Pasuchaca

ASJC Scopus subject areas

Bioengineering
Biotechnology
Biochemistry
Biochemistry, Genetics and Molecular Biology(all)
Chemistry (miscellaneous)
Applied Microbiology and Biotechnology
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.50420

Cite this

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abstract = "The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activity revealed that PsEx strongly inhibited mouse small intestine maltase activity. Taken together, these results suggest that the inhibitory effect of PsEx on α-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.",

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language = "English",

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T1 - Inhibitory effects of pasuchaca (Geranium dielsiaum) extract on α-glucosidase in mouse

AU - Karato, Mariko

AU - Yamaguchi, Kohji

AU - Takei, Shin

AU - Kino, Takao

AU - Yazawa, Kazunaga

PY - 2006

Y1 - 2006

N2 - The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activity revealed that PsEx strongly inhibited mouse small intestine maltase activity. Taken together, these results suggest that the inhibitory effect of PsEx on α-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.

AB - The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activity revealed that PsEx strongly inhibited mouse small intestine maltase activity. Taken together, these results suggest that the inhibitory effect of PsEx on α-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.

KW - α-glucosidase

KW - Diabetes

KW - Inhibitor

KW - Pasuchaca

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SN - 0916-8451

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EP - 1484

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

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ER -

Inhibitory effects of pasuchaca (Geranium dielsiaum) extract on α-glucosidase in mouse

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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