TY - JOUR
T1 - Initial results of in vivo CT imaging of contrast agents using MPPC-based photon-counting CT
AU - Sato, Daichi
AU - Arimoto, Makoto
AU - Yoshiura, Kotaro
AU - Mizuno, Tomoya
AU - Aiga, Ko
AU - Ishiguro, Kairi
AU - Tomoda, Takahiro
AU - Kawashima, Hiroki
AU - Kobayashi, Satoshi
AU - Okumura, Kenichiro
AU - Murakami, Kazuhiro
AU - Kataoka, Jun
AU - Toyoda, Takaya
AU - Sagisaka, Mayu
AU - Terazawa, Shinsuke
AU - Shiota, Satoshi
N1 - Funding Information:
We gratefully acknowledge financial support from JSPS KAKENHI Grant Numbers JP19H04483 , JP19K22924 , JST ERATO Grant Number JPMJER2102 , JST SPRING Grant Number JPMJSP2135 , the Naito Foundation , the Uehara Memorial Foundation , the Casio Science Promotion Foundation , and the JSPS Leading Initiative for Excellent Young Researchers program .
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/3
Y1 - 2023/3
N2 - X-ray computed tomography (CT) is an essential technology in modern medicine, as it enables three-dimensional non-destructive observation of the inside of the body. Contrast-enhanced CT scanning is widely performed for lesion-enhanced imaging. However, conventional X-ray CT systems integrate all incident X-ray signals, leading to the acquisition of monochromatic energy information and the prevention of material identification and quantitative evaluation of the concentration of contrast agents. Recently, photon counting CT (PC-CT) has been attracting attention as a new system for solving these problems. PC-CT utilizes the energy information of individual X-ray photons, enabling the identification of target materials. We have performed demonstrations combining the PC-CT system that we developed with fast scintillators and multi-pixel photon counters. In this study, we report on the initial results of in-vivo X-ray CT imaging with our established PC-CT system. We injected an iodine contrast agent into a mouse and visualized the spatial distribution of the contrast agent. Subsequently, we performed K-edge imaging and concentration mapping with the obtained CT images in multiple energy bands. The obtained images displayed successful three-dimensional contrast enhancement and a concentration map of the kidney and bladder in the mouse, indicating significant potential for the clinical application of this silicon photomultiplier-based PC-CT system.
AB - X-ray computed tomography (CT) is an essential technology in modern medicine, as it enables three-dimensional non-destructive observation of the inside of the body. Contrast-enhanced CT scanning is widely performed for lesion-enhanced imaging. However, conventional X-ray CT systems integrate all incident X-ray signals, leading to the acquisition of monochromatic energy information and the prevention of material identification and quantitative evaluation of the concentration of contrast agents. Recently, photon counting CT (PC-CT) has been attracting attention as a new system for solving these problems. PC-CT utilizes the energy information of individual X-ray photons, enabling the identification of target materials. We have performed demonstrations combining the PC-CT system that we developed with fast scintillators and multi-pixel photon counters. In this study, we report on the initial results of in-vivo X-ray CT imaging with our established PC-CT system. We injected an iodine contrast agent into a mouse and visualized the spatial distribution of the contrast agent. Subsequently, we performed K-edge imaging and concentration mapping with the obtained CT images in multiple energy bands. The obtained images displayed successful three-dimensional contrast enhancement and a concentration map of the kidney and bladder in the mouse, indicating significant potential for the clinical application of this silicon photomultiplier-based PC-CT system.
KW - MPPC
KW - Photon counting
KW - X-ray CT
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U2 - 10.1016/j.nima.2022.167960
DO - 10.1016/j.nima.2022.167960
M3 - Article
AN - SCOPUS:85145664341
SN - 0168-9002
VL - 1048
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
M1 - 167960
ER -