Integration of horizontal and vertical microfluidic modules for core-shell droplet generation and chemical application

Dong Hyun Yoon; Yoshito Nozaki; Daiki Tanaka; Tetsushi Sekiguchi; Shuichi Shoji

doi:10.3390/mi10090613

Integration of horizontal and vertical microfluidic modules for core-shell droplet generation and chemical application

Dong Hyun Yoon^*, Yoshito Nozaki, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

This paper presents a method for utilizing three-dimensional microfluidic channels fully to realize multiple functions in a single device. The final device structure was achieved by combining three independent modules that consisted of horizontal and vertical channels. The device allowed for the one-step generation of water-in-oil-in-water droplets without the need for partial treatment of the polydimethylsiloxane channel surface using separate modules for generating water-in-oil droplets on the horizontal plane and oil-in-water droplets on the vertical plane. The second vertically structured module provided an efficient flow for the generation of highly wettable liquid droplets, and tuning of the first horizontally structured module enabled different modes of inner-core encapsulation within the oil shell. The successful integration of the vertical and horizontal channels for core-shell droplet generation and the chemical synthesis of a metal complex within the droplets were evaluated. The proposed approach of integrating independent modules will expand and enhance the functions of microfluidic platforms.

Original language	English
Article number	613
Journal	Micromachines
Volume	10
Issue number	9
DOIs	https://doi.org/10.3390/mi10090613
Publication status	Published - 2019 Sept 1

Keywords

Device integration
Double emulsion
Microdroplet
Three-dimensional structure

ASJC Scopus subject areas

Control and Systems Engineering
Mechanical Engineering
Electrical and Electronic Engineering

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10.3390/mi10090613

Cite this

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title = "Integration of horizontal and vertical microfluidic modules for core-shell droplet generation and chemical application",

abstract = "This paper presents a method for utilizing three-dimensional microfluidic channels fully to realize multiple functions in a single device. The final device structure was achieved by combining three independent modules that consisted of horizontal and vertical channels. The device allowed for the one-step generation of water-in-oil-in-water droplets without the need for partial treatment of the polydimethylsiloxane channel surface using separate modules for generating water-in-oil droplets on the horizontal plane and oil-in-water droplets on the vertical plane. The second vertically structured module provided an efficient flow for the generation of highly wettable liquid droplets, and tuning of the first horizontally structured module enabled different modes of inner-core encapsulation within the oil shell. The successful integration of the vertical and horizontal channels for core-shell droplet generation and the chemical synthesis of a metal complex within the droplets were evaluated. The proposed approach of integrating independent modules will expand and enhance the functions of microfluidic platforms.",

keywords = "Device integration, Double emulsion, Microdroplet, Three-dimensional structure",

author = "Yoon, {Dong Hyun} and Yoshito Nozaki and Daiki Tanaka and Tetsushi Sekiguchi and Shuichi Shoji",

note = "Funding Information: This work is partly supported by Canon Medical Systems Corporation. The authors thank for MEXT Nanotechnology Platform Support Project of Waseda University. Funding Information: Funding: This work is partly supported by Canon Medical Systems Corporation. Funding Information: Acknowledgments: The authors thank for MEXT Nanotechnology Platform Support Project of Waseda University. Publisher Copyright: {\textcopyright} 2019 by the authors.",

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doi = "10.3390/mi10090613",

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AU - Yoon, Dong Hyun

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AU - Tanaka, Daiki

AU - Sekiguchi, Tetsushi

AU - Shoji, Shuichi

N1 - Funding Information: This work is partly supported by Canon Medical Systems Corporation. The authors thank for MEXT Nanotechnology Platform Support Project of Waseda University. Funding Information: Funding: This work is partly supported by Canon Medical Systems Corporation. Funding Information: Acknowledgments: The authors thank for MEXT Nanotechnology Platform Support Project of Waseda University. Publisher Copyright: © 2019 by the authors.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - This paper presents a method for utilizing three-dimensional microfluidic channels fully to realize multiple functions in a single device. The final device structure was achieved by combining three independent modules that consisted of horizontal and vertical channels. The device allowed for the one-step generation of water-in-oil-in-water droplets without the need for partial treatment of the polydimethylsiloxane channel surface using separate modules for generating water-in-oil droplets on the horizontal plane and oil-in-water droplets on the vertical plane. The second vertically structured module provided an efficient flow for the generation of highly wettable liquid droplets, and tuning of the first horizontally structured module enabled different modes of inner-core encapsulation within the oil shell. The successful integration of the vertical and horizontal channels for core-shell droplet generation and the chemical synthesis of a metal complex within the droplets were evaluated. The proposed approach of integrating independent modules will expand and enhance the functions of microfluidic platforms.

AB - This paper presents a method for utilizing three-dimensional microfluidic channels fully to realize multiple functions in a single device. The final device structure was achieved by combining three independent modules that consisted of horizontal and vertical channels. The device allowed for the one-step generation of water-in-oil-in-water droplets without the need for partial treatment of the polydimethylsiloxane channel surface using separate modules for generating water-in-oil droplets on the horizontal plane and oil-in-water droplets on the vertical plane. The second vertically structured module provided an efficient flow for the generation of highly wettable liquid droplets, and tuning of the first horizontally structured module enabled different modes of inner-core encapsulation within the oil shell. The successful integration of the vertical and horizontal channels for core-shell droplet generation and the chemical synthesis of a metal complex within the droplets were evaluated. The proposed approach of integrating independent modules will expand and enhance the functions of microfluidic platforms.

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KW - Microdroplet

KW - Three-dimensional structure

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Integration of horizontal and vertical microfluidic modules for core-shell droplet generation and chemical application

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Keywords

ASJC Scopus subject areas

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