Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

Wataru Mori; Wataru Onodera; Terutoshi Kojima; Toru Asahi; Takuya Nakanishi

doi:10.1093/chemle/upae205

Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

Wataru Mori
, Wataru Onodera
, Terutoshi Kojima
, Toru Asahi^*
, Takuya Nakanishi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.

Original language	English
Article number	upae205
Journal	Chemistry Letters
Volume	53
Issue number	11
DOIs	https://doi.org/10.1093/chemle/upae205
Publication status	Published - 2024 Nov 1

Keywords

gold electrode
intrinsically disordered proteins
protein–protein interactions

ASJC Scopus subject areas

General Chemistry

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10.1093/chemle/upae205

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title = "Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes",

abstract = "The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.",

keywords = "gold electrode, intrinsically disordered proteins, protein–protein interactions",

author = "Wataru Mori and Wataru Onodera and Terutoshi Kojima and Toru Asahi and Takuya Nakanishi",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of the Chemical Society of Japan.",

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doi = "10.1093/chemle/upae205",

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T1 - Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

AU - Mori, Wataru

AU - Onodera, Wataru

AU - Kojima, Terutoshi

AU - Asahi, Toru

AU - Nakanishi, Takuya

N1 - Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of the Chemical Society of Japan.

PY - 2024/11/1

Y1 - 2024/11/1

N2 - The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.

AB - The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.

KW - gold electrode

KW - intrinsically disordered proteins

KW - protein–protein interactions

UR - https://www.scopus.com/pages/publications/85216692573

UR - https://www.scopus.com/pages/publications/85216692573#tab=citedBy

U2 - 10.1093/chemle/upae205

DO - 10.1093/chemle/upae205

M3 - Article

AN - SCOPUS:85216692573

SN - 0366-7022

VL - 53

JO - Chemistry Letters

JF - Chemistry Letters

IS - 11

M1 - upae205

ER -

Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

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Keywords

ASJC Scopus subject areas

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