Intermolecular Interactions of Lithocholic Acid Derivatives with Phospholipid as Bilayer Membrane

Zi Chen Li, Fu Mian Li, Shinya Arase, Shinji Takeoka, Eishun Tsuchida*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Three single chain lithocholic acid derivatives with a steroidal moiety in the center of the hydrocarbon chain and two head groups at both ends of the chain were synthesized and characterized. Due to their high compatibility with phospholipids, they can be incorporated homogeneously into the phospholipid bilayer membrane. The resulting mixed vesicles showed high stability against aggregation by monitoring the turbidity change in the vesicle suspensions. The entire membrane-spanning packing thus locates the steroidal moiety at the center of the bilayer. The interaction of the steroidal moiety with lipid molecules at the center of the bilayer resulted in higher mobility of lipid molecules below the Tc of the host phospholipid membrane as clarified by temperature-dependent 1H NMR, fluorescence depolarization anisotropy, and differential scanning calorimetry (DSC). The results were compared with those of cholesterol, whose steroidal moiety is located near the surface of the membrane.

Original languageEnglish
Pages (from-to)3161-3166
Number of pages6
Issue number8
Publication statusPublished - 1995 Aug 1

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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