Interrelationship between Serum Muscle Enzymes and a Low T3 in Anorexia Nervosa

Hiroaki Kumano, Tomifusa Kuboki, Rieko Tawara, Tadashi Sasaki, Shinobu Nomura, Hiroyuki Suematsu, Etsuro Ogata

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


To determine the interrelationship between muscle dysfunction and a low T3 state, both seen in anorexia nervosa, we studied the relationship between the degree of muscle involvement, as assessed by the circulating concentration of the three muscle indicators (CPK, GOT and LDH), and serum T3 in thirty-three patients when they were admitted to the hospital. We also studied the malnutritional state, as assessed by their body weight or serum GH, serum potassium and the degree of hyperactivity exhibited. Additionally, another twelve patients were studied in order to explore the mounding phenomenon which is typically elicited in hypothyroidism. The logarithms of serum CPK and GOT correlated only with the serum T3 concentration (r= - 0.35, p<0.05; r=-0.41, p<0.05; respectively). The logarithm of serum LDH highly correlated with serum T3, the percentage of ideal body weight, and the logarithm of serum GH (r=- 0.55, p<0.01; r= - 0.66, p<0.001; r=0.43, p<0.05; respectively). The mounding phenomenon was elicited in ten out of twelve patients. In conclusion, it was implied that a low T3 state was associated with an increase in serum muscle indicators and thus with muscle dysfunction encountered in anorexia nervosa.

Original languageEnglish
Pages (from-to)583-589
Number of pages7
JournalEndocrinologia Japonica
Issue number4
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • General Engineering


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