Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence

Takehiro Ando*, M. Noguch, K. Shimaya, K. Wang, E. Kobayashi, H. Liao, T. Maruyama, Y. Mulagaki, H. Iseki, I. Sakuma

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    A lightweight intraoperative spectrum measurement system for 5-ALA induced PpIX fluorescence was developed. The developed system includes a semiconductor LASER for excitation light (output light wavelength: 405nm), a CCD spectrometer, optical fiber coupled on lens system and PC. The first prototype device has a bundled fiber which contains 6 excitation fibers around one measurement fiber. The second one uses a dichroic mirror which reflects blue light (λ≤550nm) and transmits other wavelength. The third one contains not only a dichroic mirror but also a long path filter (cut on: λ=570nm) and has improved mechanical strength. The weight of the first and the prototype probe is 45g, and the external diameter is 11mm.. The weight of this probe is 25g and the external diameter is 18mm. The probes can be positioned manually and measure 5-ALA induced PpIX fluorescence.

    Original languageEnglish
    Title of host publication7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008
    PublisherSpringer Verlag
    Number of pages4
    ISBN (Print)9783540790389
    Publication statusPublished - 2008

    Publication series

    NameIFMBE Proceedings
    Volume19 IFMBE
    ISSN (Print)1680-0737


    • 5-ALA
    • Brain tumor
    • Fluorescence measurement
    • Handheld device
    • Protoporphyrin IX

    ASJC Scopus subject areas

    • Bioengineering
    • Biomedical Engineering


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