Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence

Takehiro Ando; M. Noguch; K. Shimaya; K. Wang; E. Kobayashi; H. Liao; T. Maruyama; Y. Mulagaki; H. Iseki; I. Sakuma

doi:10.1007/978-3-540-79039-6_186

Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence

Takehiro Ando^*, M. Noguch, K. Shimaya, K. Wang, E. Kobayashi, H. Liao, T. Maruyama, Y. Mulagaki, H. Iseki, I. Sakuma

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A lightweight intraoperative spectrum measurement system for 5-ALA induced PpIX fluorescence was developed. The developed system includes a semiconductor LASER for excitation light (output light wavelength: 405nm), a CCD spectrometer, optical fiber coupled on lens system and PC. The first prototype device has a bundled fiber which contains 6 excitation fibers around one measurement fiber. The second one uses a dichroic mirror which reflects blue light (λ≤550nm) and transmits other wavelength. The third one contains not only a dichroic mirror but also a long path filter (cut on: λ=570nm) and has improved mechanical strength. The weight of the first and the prototype probe is 45g, and the external diameter is 11mm.. The weight of this probe is 25g and the external diameter is 18mm. The probes can be positioned manually and measure 5-ALA induced PpIX fluorescence.

Original language	English
Title of host publication	7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008
Publisher	Springer Verlag
Pages	754-757
Number of pages	4
ISBN (Print)	9783540790389
DOIs	https://doi.org/10.1007/978-3-540-79039-6_186
Publication status	Published - 2008

Publication series

Name	IFMBE Proceedings
Volume	19 IFMBE
ISSN (Print)	1680-0737

Keywords

5-ALA
Brain tumor
Fluorescence measurement
Handheld device
Protoporphyrin IX

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

Access to Document

10.1007/978-3-540-79039-6_186

Cite this

Ando, T., Noguch, M., Shimaya, K., Wang, K., Kobayashi, E., Liao, H., Maruyama, T., Mulagaki, Y., Iseki, H., & Sakuma, I. (2008). Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. In 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008 (pp. 754-757). (IFMBE Proceedings; Vol. 19 IFMBE). Springer Verlag. https://doi.org/10.1007/978-3-540-79039-6_186

Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. / Ando, Takehiro; Noguch, M.; Shimaya, K. et al.
7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008. Springer Verlag, 2008. p. 754-757 (IFMBE Proceedings; Vol. 19 IFMBE).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ando, T, Noguch, M, Shimaya, K, Wang, K, Kobayashi, E, Liao, H, Maruyama, T, Mulagaki, Y, Iseki, H & Sakuma, I 2008, Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. in 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008. IFMBE Proceedings, vol. 19 IFMBE, Springer Verlag, pp. 754-757. https://doi.org/10.1007/978-3-540-79039-6_186

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abstract = "A lightweight intraoperative spectrum measurement system for 5-ALA induced PpIX fluorescence was developed. The developed system includes a semiconductor LASER for excitation light (output light wavelength: 405nm), a CCD spectrometer, optical fiber coupled on lens system and PC. The first prototype device has a bundled fiber which contains 6 excitation fibers around one measurement fiber. The second one uses a dichroic mirror which reflects blue light (λ≤550nm) and transmits other wavelength. The third one contains not only a dichroic mirror but also a long path filter (cut on: λ=570nm) and has improved mechanical strength. The weight of the first and the prototype probe is 45g, and the external diameter is 11mm.. The weight of this probe is 25g and the external diameter is 18mm. The probes can be positioned manually and measure 5-ALA induced PpIX fluorescence.",

keywords = "5-ALA, Brain tumor, Fluorescence measurement, Handheld device, Protoporphyrin IX",

author = "Takehiro Ando and M. Noguch and K. Shimaya and K. Wang and E. Kobayashi and H. Liao and T. Maruyama and Y. Mulagaki and H. Iseki and I. Sakuma",

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AU - Ando, Takehiro

AU - Noguch, M.

AU - Shimaya, K.

AU - Wang, K.

AU - Kobayashi, E.

AU - Liao, H.

AU - Maruyama, T.

AU - Mulagaki, Y.

AU - Iseki, H.

AU - Sakuma, I.

PY - 2008

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N2 - A lightweight intraoperative spectrum measurement system for 5-ALA induced PpIX fluorescence was developed. The developed system includes a semiconductor LASER for excitation light (output light wavelength: 405nm), a CCD spectrometer, optical fiber coupled on lens system and PC. The first prototype device has a bundled fiber which contains 6 excitation fibers around one measurement fiber. The second one uses a dichroic mirror which reflects blue light (λ≤550nm) and transmits other wavelength. The third one contains not only a dichroic mirror but also a long path filter (cut on: λ=570nm) and has improved mechanical strength. The weight of the first and the prototype probe is 45g, and the external diameter is 11mm.. The weight of this probe is 25g and the external diameter is 18mm. The probes can be positioned manually and measure 5-ALA induced PpIX fluorescence.

AB - A lightweight intraoperative spectrum measurement system for 5-ALA induced PpIX fluorescence was developed. The developed system includes a semiconductor LASER for excitation light (output light wavelength: 405nm), a CCD spectrometer, optical fiber coupled on lens system and PC. The first prototype device has a bundled fiber which contains 6 excitation fibers around one measurement fiber. The second one uses a dichroic mirror which reflects blue light (λ≤550nm) and transmits other wavelength. The third one contains not only a dichroic mirror but also a long path filter (cut on: λ=570nm) and has improved mechanical strength. The weight of the first and the prototype probe is 45g, and the external diameter is 11mm.. The weight of this probe is 25g and the external diameter is 18mm. The probes can be positioned manually and measure 5-ALA induced PpIX fluorescence.

KW - 5-ALA

KW - Brain tumor

KW - Fluorescence measurement

KW - Handheld device

KW - Protoporphyrin IX

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BT - 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008

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Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence

Abstract

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