Involvement of μ1-opioid receptor on oxycodone-induced antinociception in diabetic mice

Chihiro Nozaki; Junzo Kamei

doi:10.1016/j.ejphar.2007.01.021

Involvement of μ₁-opioid receptor on oxycodone-induced antinociception in diabetic mice

Chihiro Nozaki, Junzo Kamei^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The effect of naloxonazine, a selective μ₁-opioid receptor antagonist, on oxycodone-induced antinociception was examined in streptozotocin-induced diabetic mice. Oxycodone (5 mg/kg, s.c.) induced significant antinociception in both non-diabetic and diabetic mice. This antinociceptive effect of oxycodone was completely antagonized by pretreatment with naloxonazine (35 mg/kg, s.c.) in both non-diabetic and diabetic mice. The selective κ-opioid receptor antagonist nor-binaltorphimine (20 mg/kg, s.c.) also antagonized oxycodone-induced antinociception in diabetic mice, but only had a partial effect in non-diabetic mice. These results suggest that although primarily interacts with μ₁-opioid receptor, κ-opioid receptors are also strongly involved in oxycodone-induced antinociception.

Original language	English
Pages (from-to)	160-162
Number of pages	3
Journal	European Journal of Pharmacology
Volume	560
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ejphar.2007.01.021
Publication status	Published - 2007 Apr 10
Externally published	Yes

Keywords

Diabetes
Hyperalgesia
Oxycodone
κ-Opioid receptor
μ-Opioid receptor

ASJC Scopus subject areas

Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejphar.2007.01.021

Cite this

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title = "Involvement of μ1-opioid receptor on oxycodone-induced antinociception in diabetic mice",

abstract = "The effect of naloxonazine, a selective μ1-opioid receptor antagonist, on oxycodone-induced antinociception was examined in streptozotocin-induced diabetic mice. Oxycodone (5 mg/kg, s.c.) induced significant antinociception in both non-diabetic and diabetic mice. This antinociceptive effect of oxycodone was completely antagonized by pretreatment with naloxonazine (35 mg/kg, s.c.) in both non-diabetic and diabetic mice. The selective κ-opioid receptor antagonist nor-binaltorphimine (20 mg/kg, s.c.) also antagonized oxycodone-induced antinociception in diabetic mice, but only had a partial effect in non-diabetic mice. These results suggest that although primarily interacts with μ1-opioid receptor, κ-opioid receptors are also strongly involved in oxycodone-induced antinociception.",

keywords = "Diabetes, Hyperalgesia, Oxycodone, κ-Opioid receptor, μ-Opioid receptor",

author = "Chihiro Nozaki and Junzo Kamei",

note = "Funding Information: This work was supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan. We would like to thank Drs. K. Kawai and T. Suzuki (Toray Industries, Inc.) for their constant support.",

year = "2007",

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day = "10",

doi = "10.1016/j.ejphar.2007.01.021",

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AU - Nozaki, Chihiro

AU - Kamei, Junzo

N1 - Funding Information: This work was supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan. We would like to thank Drs. K. Kawai and T. Suzuki (Toray Industries, Inc.) for their constant support.

PY - 2007/4/10

Y1 - 2007/4/10

N2 - The effect of naloxonazine, a selective μ1-opioid receptor antagonist, on oxycodone-induced antinociception was examined in streptozotocin-induced diabetic mice. Oxycodone (5 mg/kg, s.c.) induced significant antinociception in both non-diabetic and diabetic mice. This antinociceptive effect of oxycodone was completely antagonized by pretreatment with naloxonazine (35 mg/kg, s.c.) in both non-diabetic and diabetic mice. The selective κ-opioid receptor antagonist nor-binaltorphimine (20 mg/kg, s.c.) also antagonized oxycodone-induced antinociception in diabetic mice, but only had a partial effect in non-diabetic mice. These results suggest that although primarily interacts with μ1-opioid receptor, κ-opioid receptors are also strongly involved in oxycodone-induced antinociception.

AB - The effect of naloxonazine, a selective μ1-opioid receptor antagonist, on oxycodone-induced antinociception was examined in streptozotocin-induced diabetic mice. Oxycodone (5 mg/kg, s.c.) induced significant antinociception in both non-diabetic and diabetic mice. This antinociceptive effect of oxycodone was completely antagonized by pretreatment with naloxonazine (35 mg/kg, s.c.) in both non-diabetic and diabetic mice. The selective κ-opioid receptor antagonist nor-binaltorphimine (20 mg/kg, s.c.) also antagonized oxycodone-induced antinociception in diabetic mice, but only had a partial effect in non-diabetic mice. These results suggest that although primarily interacts with μ1-opioid receptor, κ-opioid receptors are also strongly involved in oxycodone-induced antinociception.

KW - Diabetes

KW - Hyperalgesia

KW - Oxycodone

KW - κ-Opioid receptor

KW - μ-Opioid receptor

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