Involvement of strawberry notch homologue 1 in neurite outgrowth of cortical neurons

Munkhsoyol Erkhembaatar, Iroha Yamamoto, Fuduki Inoguchi, Kosuke Taki, Satoru Yamagishi, Leanne Delaney, Nishibe Mariko, Takaya Abe, Hiroshi Kiyonari, Carina Hanashima, Hayato Naka-kaneda, Dai Ihara, Yu Katsuyama*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


When the regulation of axonal and dendritic growth is altered, the neuronal network becomes disordered, which may contribute to the development of psychiatric disorders. Some genome analyses have suggested relationships between mutations in strawberry notch homologue 1 (SBNO1) and neurodevelopmental disorders. However, the function of SBNO1 has not yet been reported. Here, SBNO1 expression pattern during the development of the cerebral cortex in mice was examined. SBNO1 was strongly expressed in the cortical plate and its expression was maintained at a low level during the postnatal stage. CRISPR/Cas9-based knockout of Sbno1 in Neuro2A cultured cells showed delayed growth of neurites. A cortical neuron-specific conditional knockout mouse was constructed, which resulted in hypotrophy of axon bundles and dendrites in cortical neurons. Thus, when mutated, SBNO1 is a candidate gene for psychiatric diseases, such as schizophrenia, as suggested by human genome studies.

Original languageEnglish
Pages (from-to)379-394
Number of pages16
JournalDevelopment Growth and Differentiation
Issue number7
Publication statusPublished - 2022 Sept


  • Nex-Cre
  • cortical neurons
  • cortical plate
  • neurite growth
  • strawberry notch

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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