Involvement of the suprachiasmatic nucleus in body temperature modulation by food deprivation in rats

Su Liu; Xiao Ming Chen; Tamae Yoda; Kei Nagashima; Yutaka Fukuda; Kazuyuki Kanosue

doi:10.1016/S0006-8993(01)03374-1

Involvement of the suprachiasmatic nucleus in body temperature modulation by food deprivation in rats

Su Liu, Xiao Ming Chen, Tamae Yoda, Kei Nagashima, Yutaka Fukuda, Kazuyuki Kanosue^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Recently we found that food-deprived rats kept under a light-dark cycle showed a progressive reduction in body temperature during the light phase on each subsequent day while body temperature in the dark phase did not differ from baseline values. In this study, we investigated the effect of lesioning the hypothalamic suprachiasmatic nucleus (SCN) on body temperature modulation by food deprivation. In the SCN-lesioned rats in which daily rhythms of body temperature and activity were abolished, body temperature was unchanged by food deprivation. We also examined the effect of food deprivation on the daily changes in Fos expression in the SCN. Under normal fed conditions the number of SCN cells expressing Fos is high during the day and low at night. Food deprivation attenuated the amplitude of this daily change in Fos expression in the SCN. This tendency was prominent in the dorsal part of the SCN, while the ventral part showed no effect of food deprivation. These findings suggest that the SCN plays some role in body temperature modulation due to food deprivation.

Original language	English
Pages (from-to)	26-36
Number of pages	11
Journal	Brain Research
Volume	929
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(01)03374-1
Publication status	Published - 2002 Mar 1
Externally published	Yes

Keywords

Body temperature
Circadian rhythm
Fos

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(01)03374-1

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title = "Involvement of the suprachiasmatic nucleus in body temperature modulation by food deprivation in rats",

abstract = "Recently we found that food-deprived rats kept under a light-dark cycle showed a progressive reduction in body temperature during the light phase on each subsequent day while body temperature in the dark phase did not differ from baseline values. In this study, we investigated the effect of lesioning the hypothalamic suprachiasmatic nucleus (SCN) on body temperature modulation by food deprivation. In the SCN-lesioned rats in which daily rhythms of body temperature and activity were abolished, body temperature was unchanged by food deprivation. We also examined the effect of food deprivation on the daily changes in Fos expression in the SCN. Under normal fed conditions the number of SCN cells expressing Fos is high during the day and low at night. Food deprivation attenuated the amplitude of this daily change in Fos expression in the SCN. This tendency was prominent in the dorsal part of the SCN, while the ventral part showed no effect of food deprivation. These findings suggest that the SCN plays some role in body temperature modulation due to food deprivation.",

keywords = "Body temperature, Circadian rhythm, Fos",

author = "Su Liu and Chen, {Xiao Ming} and Tamae Yoda and Kei Nagashima and Yutaka Fukuda and Kazuyuki Kanosue",

note = "Funding Information: The authors thank Professor K. Honma and Dr. S. Honma (Hokkaido University) for their advice on the destruction of the SCN, and Dr. Larry I. Crawshaw for his critical comments throughout the experiment. This study was partly supported by Grants-in Aid for Scientific Research from the Ministry of Education, Sciences and Culture of Japan (grant Nos. 07044260 and 11557003).",

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AU - Chen, Xiao Ming

AU - Yoda, Tamae

AU - Nagashima, Kei

AU - Fukuda, Yutaka

AU - Kanosue, Kazuyuki

N1 - Funding Information: The authors thank Professor K. Honma and Dr. S. Honma (Hokkaido University) for their advice on the destruction of the SCN, and Dr. Larry I. Crawshaw for his critical comments throughout the experiment. This study was partly supported by Grants-in Aid for Scientific Research from the Ministry of Education, Sciences and Culture of Japan (grant Nos. 07044260 and 11557003).

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Recently we found that food-deprived rats kept under a light-dark cycle showed a progressive reduction in body temperature during the light phase on each subsequent day while body temperature in the dark phase did not differ from baseline values. In this study, we investigated the effect of lesioning the hypothalamic suprachiasmatic nucleus (SCN) on body temperature modulation by food deprivation. In the SCN-lesioned rats in which daily rhythms of body temperature and activity were abolished, body temperature was unchanged by food deprivation. We also examined the effect of food deprivation on the daily changes in Fos expression in the SCN. Under normal fed conditions the number of SCN cells expressing Fos is high during the day and low at night. Food deprivation attenuated the amplitude of this daily change in Fos expression in the SCN. This tendency was prominent in the dorsal part of the SCN, while the ventral part showed no effect of food deprivation. These findings suggest that the SCN plays some role in body temperature modulation due to food deprivation.

AB - Recently we found that food-deprived rats kept under a light-dark cycle showed a progressive reduction in body temperature during the light phase on each subsequent day while body temperature in the dark phase did not differ from baseline values. In this study, we investigated the effect of lesioning the hypothalamic suprachiasmatic nucleus (SCN) on body temperature modulation by food deprivation. In the SCN-lesioned rats in which daily rhythms of body temperature and activity were abolished, body temperature was unchanged by food deprivation. We also examined the effect of food deprivation on the daily changes in Fos expression in the SCN. Under normal fed conditions the number of SCN cells expressing Fos is high during the day and low at night. Food deprivation attenuated the amplitude of this daily change in Fos expression in the SCN. This tendency was prominent in the dorsal part of the SCN, while the ventral part showed no effect of food deprivation. These findings suggest that the SCN plays some role in body temperature modulation due to food deprivation.

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Involvement of the suprachiasmatic nucleus in body temperature modulation by food deprivation in rats

Abstract

Keywords

ASJC Scopus subject areas

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