Ir(I)-catalyzed enantioselective secondary sp 3 C-H bond activation of 2-(alkylamino)pyridines with alkenes

Shiguang Pan; Kohei Endo; Takanori Shibata

doi:10.1021/ol201907w

Ir(I)-catalyzed enantioselective secondary sp ³ C-H bond activation of 2-(alkylamino)pyridines with alkenes

Shiguang Pan, Kohei Endo, Takanori Shibata^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Abstract

A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp ³ C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.

Original language	English
Pages (from-to)	4692-4695
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	17
DOIs	https://doi.org/10.1021/ol201907w
Publication status	Published - 2011 Sept 2

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol201907w

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title = "Ir(I)-catalyzed enantioselective secondary sp 3 C-H bond activation of 2-(alkylamino)pyridines with alkenes",

abstract = "A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp 3 C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.",

author = "Shiguang Pan and Kohei Endo and Takanori Shibata",

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AU - Endo, Kohei

AU - Shibata, Takanori

PY - 2011/9/2

Y1 - 2011/9/2

N2 - A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp 3 C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.

AB - A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp 3 C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.

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JF - Organic Letters

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Ir(I)-catalyzed enantioselective secondary sp ³ C-H bond activation of 2-(alkylamino)pyridines with alkenes

Abstract

ASJC Scopus subject areas

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