TY - JOUR
T1 - Kulolide
T2 - A cytotoxic depsipeptide from a cephalaspidean mollusk, Philinopsis speciosa
AU - Reese, Michael T.
AU - Gulavita, Nanda K.
AU - Nakao, Yoichi
AU - Hamann, Mark T.
AU - Yoshida, Wesley Y.
AU - Coval, Stephen J.
AU - Scheuer, Paul J.
PY - 1996/11/13
Y1 - 1996/11/13
N2 - Kulolide, a cyclic depsipeptide, was isolated from a cephalaspidean mollusk, Philinopsis speciosa Pease, 1860. Kulolide is made up of five amino acid residues, one each of L-Ala, L-Pro, and N-Me-D-Val and two of L-Val, and two carboxylic acids, L-3-phenyllactic acid and the unprecedented (R)-3-hydroxy-2,2-dimethyl-7-octynoic acid. The kulolide structure was elucidated by spectral techniques and hydrolytic reactions. Kulolide is active against L-1210 leukemia cells and P388 murine leukemia cells at IC50 values of 0.7 and 2.l μg/mL, respectively. Kulolide caused morphological change against rat 3Y1 fibroblast cells at the concentration of 50 μM.
AB - Kulolide, a cyclic depsipeptide, was isolated from a cephalaspidean mollusk, Philinopsis speciosa Pease, 1860. Kulolide is made up of five amino acid residues, one each of L-Ala, L-Pro, and N-Me-D-Val and two of L-Val, and two carboxylic acids, L-3-phenyllactic acid and the unprecedented (R)-3-hydroxy-2,2-dimethyl-7-octynoic acid. The kulolide structure was elucidated by spectral techniques and hydrolytic reactions. Kulolide is active against L-1210 leukemia cells and P388 murine leukemia cells at IC50 values of 0.7 and 2.l μg/mL, respectively. Kulolide caused morphological change against rat 3Y1 fibroblast cells at the concentration of 50 μM.
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U2 - 10.1021/ja9620301
DO - 10.1021/ja9620301
M3 - Article
AN - SCOPUS:0029860844
SN - 0002-7863
VL - 118
SP - 11081
EP - 11084
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 45
ER -