TY - JOUR
T1 - Lack of association between genotype score and sprint/power performance in the Japanese population
AU - Miyamoto-Mikami, Eri
AU - Murakami, Haruka
AU - Tsuchie, Hiroyasu
AU - Takahashi, Hideyuki
AU - Ohiwa, Nao
AU - Miyachi, Motohiko
AU - Kawahara, Takashi
AU - Fuku, Noriyuki
N1 - Funding Information:
This work was supported in part by grants from the Grant-in-Aid for Scientific Research (B) ( 15H03081 to N.F.) of the Ministry of Education, Culture, Sports, Science and Technology-Japan and by a grant-in-aid for scientific research (to M.M.) from the Ministry of Health, Labor, and Welfare-Japan . E.M. was a recipient of a Grant-in-Aid for JSPS Fellow from the Japan Society for the Promotion of Science .
Publisher Copyright:
© 2016 Sports Medicine Australia
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives This study aimed to examine the association between a total genotype score (TGS) based on previously published genetic polymorphism candidates and differences in sprint/power performance. Design Case–control association study. Methods We analysed 21 polymorphisms, which have previously been associated with sprint/power performance and related phenotypes, in 211 Japanese sprint/power track and field athletes (77 regional, 72 national, and 62 international athletes) and 649 Japanese controls using the TaqMan SNP genotyping assay. We calculated the TGS (maximum value of 100 for the theoretically optimal polygenic score) for the 21 polymorphisms. Results All groups exhibited similar TGSs (control: 55.9 ± 7.2, regional: 55.1 ± 7.1, national: 56.1 ± 7.4, and international: 56.0 ± 7.8, p = 0.827 by one-way analysis of variance). Nine of the 21 polymorphisms had the same direction of effect (odds ratio >1.0) as in previous studies, while 12 had the opposite direction of effect (odds ratio <1.0). Three polymorphisms (rs699 in AGT, rs41274853 in CNTFR, and rs7832552 in TRHR), which had the same direction of effect as in previous studies, were associated with international sprint/power athlete status (p < 0.05). However, after multiple testing corrections, the statistical significance of these polymorphisms was not retained. Conclusions These results suggest that TGSs based on the 21 previously published sprint/power performance-associated polymorphisms did not influence the sprint/power athlete status of Japanese track and field athletes. However, our results maintain the possibility that three of these polymorphisms might be associated with sprint/power performance.
AB - Objectives This study aimed to examine the association between a total genotype score (TGS) based on previously published genetic polymorphism candidates and differences in sprint/power performance. Design Case–control association study. Methods We analysed 21 polymorphisms, which have previously been associated with sprint/power performance and related phenotypes, in 211 Japanese sprint/power track and field athletes (77 regional, 72 national, and 62 international athletes) and 649 Japanese controls using the TaqMan SNP genotyping assay. We calculated the TGS (maximum value of 100 for the theoretically optimal polygenic score) for the 21 polymorphisms. Results All groups exhibited similar TGSs (control: 55.9 ± 7.2, regional: 55.1 ± 7.1, national: 56.1 ± 7.4, and international: 56.0 ± 7.8, p = 0.827 by one-way analysis of variance). Nine of the 21 polymorphisms had the same direction of effect (odds ratio >1.0) as in previous studies, while 12 had the opposite direction of effect (odds ratio <1.0). Three polymorphisms (rs699 in AGT, rs41274853 in CNTFR, and rs7832552 in TRHR), which had the same direction of effect as in previous studies, were associated with international sprint/power athlete status (p < 0.05). However, after multiple testing corrections, the statistical significance of these polymorphisms was not retained. Conclusions These results suggest that TGSs based on the 21 previously published sprint/power performance-associated polymorphisms did not influence the sprint/power athlete status of Japanese track and field athletes. However, our results maintain the possibility that three of these polymorphisms might be associated with sprint/power performance.
KW - Athletes
KW - Athletic performance
KW - Polygenic profile
KW - Polymorphism
KW - Track and field
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U2 - 10.1016/j.jsams.2016.06.005
DO - 10.1016/j.jsams.2016.06.005
M3 - Article
C2 - 27380726
AN - SCOPUS:85003467403
SN - 1440-2440
VL - 20
SP - 98
EP - 103
JO - Journal of Science and Medicine in Sport
JF - Journal of Science and Medicine in Sport
IS - 1
ER -