Lanthanide metal complexes for the hydrolysis of linear DNAs

Tetsuro Shiiba, Koji Yonezawa, Naoya Takeda, Yoichi Matsumoto, Morio Yashiro, Makoto Komiyama*

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

42 Citations (Scopus)


Lanthanum (III) and cerium (III) complexes of macrocyclic ligands efficiently hydrolyze the phosphodiester linkages in linear DNAs at pH 7.2 and 30-50°C. Both single-stranded and double-stranded DNAs are hydrolysed without specific base preference, yielding predominantly 3′-phosphate termini. The potential of these complexes as the catalytic centers of artificial hydrolytic nucleases are indicated.

Original languageEnglish
Pages (from-to)L21-L25
JournalJournal of Molecular Catalysis
Issue number1
Publication statusPublished - 1993 Sept 21
Externally publishedYes


  • DNA hydrolysis
  • artificial nuclease
  • cerium (III) complex
  • lanthanide (III) complex
  • lanthanum (III) complex

ASJC Scopus subject areas

  • Engineering(all)


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