Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men

Seiji Maeda*, Asako Miyaki, Hiroshi Kumagai, Miki Eto, Rina So, Kiyoji Tanaka, Ryuichi Ajisaka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Background: Increased arterial stiffness is an independent risk factor for cardiovascular disease. Arterial stiffness is higher in obese individuals than in nonobese individuals. Lifestyle modifications (i.e. exercise and dietary modification) decrease arterial stiffness in obese individuals. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, an enzyme responsible for the generation of nitric oxide. AIM: The aim of this study was to examine whether lifestyle modifications affect circulating levels of ADMA in overweight and obese men and, if they do, whether ADMA is involved in the mechanism underlying the decrease in arterial stiffness with lifestyle modification. METHODS: Seventeen overweight and obese men (BMI: 29.8±0.8 kg/m) completed a 12-week lifestyle modification program, which included aerobic exercise and dietary modification. Before and after the intervention, we evaluated brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, and plasma ADMA concentration in all participants. RESULTS: After the 12-week lifestyle modification program, BMI and baPWV decreased significantly and the plasma ADMA concentration decreased markedly in overweight and obese men. There was a significant positive correlation between percent change in baPWV and plasma ADMA concentration. CONCLUSION: Lifestyle modifications reduce arterial stiffness and plasma ADMA concentration in overweight and obese individuals. A decrease in arterial stiffness was associated with a corresponding reduction in plasma ADMA concentrations. These results suggest that reductions in ADMA may be an important mechanism underlying the beneficial effect of lifestyle modification on arterial stiffness.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalCoronary Artery Disease
Issue number7
Publication statusPublished - 2013 Nov
Externally publishedYes


  • asymmetric dimethylarginine
  • dietary modification
  • exercise
  • obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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