Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Shogo Haraguchi; Masaki Kamata; Takuma Tokita; Kei Ichiro Tashiro; Miku Sato; Mitsuki Nozaki; Mayumi Okamoto-Katsuyama; Isao Shimizu; Guofeng Han; Vishwajit S. Chowdhury; Xiao Feng Lei; Takuro Miyazaki; Joo Ri Kim-Kaneyama; Tomoya Nakamachi; Kouhei Matsuda; Hirokazu Ohtaki; Toshinobu Tokumoto; Tetsuya Tachibana; Akira Miyazaki; Kazuyoshi Tsutsui

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Shogo Haraguchi^*, Masaki Kamata, Takuma Tokita, Kei Ichiro Tashiro, Miku Sato, Mitsuki Nozaki, Mayumi Okamoto-Katsuyama, Isao Shimizu, Guofeng Han, Vishwajit S. Chowdhury, Xiao Feng Lei, Takuro Miyazaki, Joo Ri Kim-Kaneyama, Tomoya Nakamachi, Kouhei Matsuda, Hirokazu Ohtaki, Toshinobu Tokumoto, Tetsuya Tachibana, Akira Miyazaki, Kazuyoshi Tsutsui

^*Corresponding author for this work

School of Education

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks

Original language	English
Journal	eLife
Volume	8
Publication status	Published - 2019 Sept

ASJC Scopus subject areas

Neuroscience(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)

Cite this

Haraguchi, S., Kamata, M., Tokita, T., Tashiro, K. I., Sato, M., Nozaki, M., Okamoto-Katsuyama, M., Shimizu, I., Han, G., Chowdhury, V. S., Lei, X. F., Miyazaki, T., Kim-Kaneyama, J. R., Nakamachi, T., Matsuda, K., Ohtaki, H., Tokumoto, T., Tachibana, T., Miyazaki, A., & Tsutsui, K. (2019). Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms. eLife, 8.

Haraguchi, S, Kamata, M, Tokita, T, Tashiro, KI, Sato, M, Nozaki, M, Okamoto-Katsuyama, M, Shimizu, I, Han, G, Chowdhury, VS, Lei, XF, Miyazaki, T, Kim-Kaneyama, JR, Nakamachi, T, Matsuda, K, Ohtaki, H, Tokumoto, T, Tachibana, T, Miyazaki, A & Tsutsui, K 2019, 'Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms', eLife, vol. 8.

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title = "Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms",

abstract = "The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks",

author = "Shogo Haraguchi and Masaki Kamata and Takuma Tokita and Tashiro, {Kei Ichiro} and Miku Sato and Mitsuki Nozaki and Mayumi Okamoto-Katsuyama and Isao Shimizu and Guofeng Han and Chowdhury, {Vishwajit S.} and Lei, {Xiao Feng} and Takuro Miyazaki and Kim-Kaneyama, {Joo Ri} and Tomoya Nakamachi and Kouhei Matsuda and Hirokazu Ohtaki and Toshinobu Tokumoto and Tetsuya Tachibana and Akira Miyazaki and Kazuyoshi Tsutsui",

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AU - Haraguchi, Shogo

AU - Kamata, Masaki

AU - Tokita, Takuma

AU - Tashiro, Kei Ichiro

AU - Sato, Miku

AU - Nozaki, Mitsuki

AU - Okamoto-Katsuyama, Mayumi

AU - Shimizu, Isao

AU - Han, Guofeng

AU - Chowdhury, Vishwajit S.

AU - Lei, Xiao Feng

AU - Miyazaki, Takuro

AU - Kim-Kaneyama, Joo Ri

AU - Nakamachi, Tomoya

AU - Matsuda, Kouhei

AU - Ohtaki, Hirokazu

AU - Tokumoto, Toshinobu

AU - Tachibana, Tetsuya

AU - Miyazaki, Akira

AU - Tsutsui, Kazuyoshi

PY - 2019/9

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AB - The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks

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Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Abstract

ASJC Scopus subject areas

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