Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines

Jun Nakanishi; Hidekazu Nakayama; Takahiro Shimizu; Haruhisa Ishida; Yukiko Kikuchi; Kazuo Yamaguchi; Yasuhiro Horiike

doi:10.1021/ja809236a

Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines

Jun Nakanishi^*, Hidekazu Nakayama, Takahiro Shimizu, Haruhisa Ishida, Yukiko Kikuchi, Kazuo Yamaguchi, Yasuhiro Horiike

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.

Original language	English
Pages (from-to)	3822-3823
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	11
DOIs	https://doi.org/10.1021/ja809236a
Publication status	Published - 2009 Mar 25
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja809236a

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AU - Kikuchi, Yukiko

AU - Yamaguchi, Kazuo

AU - Horiike, Yasuhiro

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Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines

Abstract

ASJC Scopus subject areas

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