Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.

Makoto Yuasa; Kenichi Oyaizu; Aiko Horiuchi; Akihiko Ogata; Tomomi Hatsugai; Aritomo Yamaguchi; Hiroyoshi Kawakami

doi:10.1021/mp049936v

Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.

Makoto Yuasa^*, Kenichi Oyaizu, Aiko Horiuchi, Akihiko Ogata, Tomomi Hatsugai, Aritomo Yamaguchi, Hiroyoshi Kawakami

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.

Original language	English
Pages (from-to)	387-389
Number of pages	3
Journal	Molecular pharmaceutics
Volume	1
Issue number	5
DOIs	https://doi.org/10.1021/mp049936v
Publication status	Published - 2004
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

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abstract = "A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.",

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AU - Yuasa, Makoto

AU - Oyaizu, Kenichi

AU - Horiuchi, Aiko

AU - Ogata, Akihiko

AU - Hatsugai, Tomomi

AU - Yamaguchi, Aritomo

AU - Kawakami, Hiroyoshi

PY - 2004

Y1 - 2004

N2 - A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.

AB - A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.

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Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.

Abstract

ASJC Scopus subject areas

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