@article{9ad3f126a9f14784b73a6b016460dedd,
title = "Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes",
abstract = "Specific conditions, such as exposure to cold, can induce the production of brown-like adipocytes in white adipose tissue. These adipocytes express high levels of uncoupling protein 1 (UCP1) and energy expended by generating heat. Thus, these are a potential target for the prevention or treatment of obesity. The present study involved a comprehensive analysis of the adipose tissue to understand the relationship between long non-coding RNA (lncRNA) 2310069B03Rik and UCP1. Cold exposure increased both lncRNA 2310069B03Rik and Ucp1 expression in inguinal white adipose tissue (iWAT). However, overexpression of lncRNA 2310069B03Rik suppressed the Ucp1 mRNA expression and the promoter activity of UCP1 in the iWAT primary adipocytes. In addition, compared to the early induction of Ucp1 expression by cold stimulation, the induction of lncRNA 2310069B03Rik expression was later. These results suggest that lncRNA 2310069B03Rik functions as a suppression factor of Ucp1 expression.",
keywords = "Adipocyte, browning, cold exposure, long non-coding RNA",
author = "Mari Iwase and Shoko Sakai and Shigeto Seno and Yeh, {Yu Sheng} and Tony Kuo and Haruya Takahashi and Wataru Nomura and Jheng, {Huei Fen} and Paul Horton and Naoki Osato and Hideo Matsuda and Kazuo Inoue and Teruo Kawada and Tsuyoshi Goto",
note = "Funding Information: This work was supported by the Japan Society for the Promotion of Science [JP16H02551, JP18H04124, JP19H02910]. This work was supported by JSPS KAKENHI Grant Numbers JP16H02551, JP18H04124 and JP19H02910. The authors thank M. Komori and R. Yoshii for kindly providing technical assistance and secretarial support. We also appreciate S. Kajimura (University of California, San Francisco) for providing the primary WAT cell line. Funding Information: This work was supported by JSPS KAKENHI Grant Numbers JP16H02551, JP18H04124 and JP19H02910. The authors thank M. Komori and R. Yoshii for kindly providing technical assistance and secretarial support. We also appreciate S. Kajimura (University of California, San Francisco) for providing the primary WAT cell line. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Japan Society for Bioscience, Biotechnology, and Agrochemistry.",
year = "2020",
month = feb,
day = "1",
doi = "10.1080/09168451.2019.1677451",
language = "English",
volume = "84",
pages = "305--313",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "2",
}