Long-term potentiation in the optic tectum of rainbow trout

Masae Kinoshita; Toshiyuki Hosokawa; Akihisa Urano; Etsuro Ito

doi:10.1016/j.neulet.2004.08.017

Long-term potentiation in the optic tectum of rainbow trout

Masae Kinoshita, Toshiyuki Hosokawa, Akihisa Urano, Etsuro Ito

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We examined synaptic plasticity in the optic tectum of rainbow trout by extracellular recordings. We found that the field-excitatory postsynaptic potential in the retinotectal synapses was potentiated by repetitive stimuli of 1.0 Hz for 20 s to the retinotectal afferents. The long-term potentiation (LTP) developed slowly, and was maintained for at least 2 h. Applications of an antagonist for N-methyl-d-aspartic acid (NMDA) receptors or Mg ²⁺-free saline showed that activation of NMDA receptors was required to form the LTP beyond the induction period. The present findings indicate that presynaptic stimulation in the retinotectal synapses causes LTP mediated by NMDA receptors in the optic tectum of rainbow trout.

Original language	English
Pages (from-to)	146-150
Number of pages	5
Journal	Neuroscience Letters
Volume	370
Issue number	2-3
DOIs	https://doi.org/10.1016/j.neulet.2004.08.017
Publication status	Published - 2004 Nov 11
Externally published	Yes

Keywords

AMPA
Glutamate receptor
NMDA
Periventricular neuron
Teleost

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neulet.2004.08.017

Cite this

@article{ed6fc9a2fedd47938ebd86c88918af47,

title = "Long-term potentiation in the optic tectum of rainbow trout",

abstract = "We examined synaptic plasticity in the optic tectum of rainbow trout by extracellular recordings. We found that the field-excitatory postsynaptic potential in the retinotectal synapses was potentiated by repetitive stimuli of 1.0 Hz for 20 s to the retinotectal afferents. The long-term potentiation (LTP) developed slowly, and was maintained for at least 2 h. Applications of an antagonist for N-methyl-d-aspartic acid (NMDA) receptors or Mg 2+-free saline showed that activation of NMDA receptors was required to form the LTP beyond the induction period. The present findings indicate that presynaptic stimulation in the retinotectal synapses causes LTP mediated by NMDA receptors in the optic tectum of rainbow trout.",

keywords = "AMPA, Glutamate receptor, NMDA, Periventricular neuron, Teleost",

author = "Masae Kinoshita and Toshiyuki Hosokawa and Akihisa Urano and Etsuro Ito",

note = "Funding Information: We thank Dr. Takeshi Nakamura for his helpful comments. This work was supported by a Grant-in-Aid (No. 09105) as a Research Fellowship to Young Scientists from the Japan Society for the Promotion of Science to M.K., a Grant-in-Aid (No. 10102001) for Specially Promoted Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to A.U., and by Grants-in-Aid (Nos. 15014201 and 16014201) for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan to E.I.",

year = "2004",

month = nov,

day = "11",

doi = "10.1016/j.neulet.2004.08.017",

language = "English",

volume = "370",

pages = "146--150",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - Long-term potentiation in the optic tectum of rainbow trout

AU - Kinoshita, Masae

AU - Hosokawa, Toshiyuki

AU - Urano, Akihisa

AU - Ito, Etsuro

N1 - Funding Information: We thank Dr. Takeshi Nakamura for his helpful comments. This work was supported by a Grant-in-Aid (No. 09105) as a Research Fellowship to Young Scientists from the Japan Society for the Promotion of Science to M.K., a Grant-in-Aid (No. 10102001) for Specially Promoted Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to A.U., and by Grants-in-Aid (Nos. 15014201 and 16014201) for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan to E.I.

PY - 2004/11/11

Y1 - 2004/11/11

N2 - We examined synaptic plasticity in the optic tectum of rainbow trout by extracellular recordings. We found that the field-excitatory postsynaptic potential in the retinotectal synapses was potentiated by repetitive stimuli of 1.0 Hz for 20 s to the retinotectal afferents. The long-term potentiation (LTP) developed slowly, and was maintained for at least 2 h. Applications of an antagonist for N-methyl-d-aspartic acid (NMDA) receptors or Mg 2+-free saline showed that activation of NMDA receptors was required to form the LTP beyond the induction period. The present findings indicate that presynaptic stimulation in the retinotectal synapses causes LTP mediated by NMDA receptors in the optic tectum of rainbow trout.

AB - We examined synaptic plasticity in the optic tectum of rainbow trout by extracellular recordings. We found that the field-excitatory postsynaptic potential in the retinotectal synapses was potentiated by repetitive stimuli of 1.0 Hz for 20 s to the retinotectal afferents. The long-term potentiation (LTP) developed slowly, and was maintained for at least 2 h. Applications of an antagonist for N-methyl-d-aspartic acid (NMDA) receptors or Mg 2+-free saline showed that activation of NMDA receptors was required to form the LTP beyond the induction period. The present findings indicate that presynaptic stimulation in the retinotectal synapses causes LTP mediated by NMDA receptors in the optic tectum of rainbow trout.

KW - AMPA

KW - Glutamate receptor

KW - NMDA

KW - Periventricular neuron

KW - Teleost

UR - http://www.scopus.com/inward/record.url?scp=5644253185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5644253185&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.08.017

DO - 10.1016/j.neulet.2004.08.017

M3 - Article

C2 - 15488312

AN - SCOPUS:5644253185

SN - 0304-3940

VL - 370

SP - 146

EP - 150

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2-3

ER -

Long-term potentiation in the optic tectum of rainbow trout

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this