Lordosis-inhibiting effect of progesterone in male and female rats with septal lesions

Motoyasu Satou, Korehito Yamanouchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The inhibitory role of progesterone (P) in regulating lordosis was investigated in male and female rats with septal lesions (SL). Male rats with SL showed lordosis quotients (LQ) as high as female rats with SL and female control rats without brain surgery after injection of 50 μg/kg estradiol benzoate (EB) followed by 0.5 mg P 44 h later. Even when primed with 5 mg P 1 h prior to the 50 μg EB-injection, the mean LQs were still high in all groups. When the dose of EB was decreased to 5 μg/kg, all rats showed high-score LQs. In contrast, all animals in both male and female in which 5 mg P was injected 1 h before 5 μg EB, showed low LQs. These results suggest that P is effective in suppressing lordosis enhanced by estrogen in either male rats or females. Furthermore, the high dose of estrogen overcomes the inhibitory action of P on lordosis in both sexes. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalBrain Research Bulletin
Issue number3
Publication statusPublished - 2000


  • Lordosis-inhibition
  • Male rat
  • Progesterone
  • Septal lesion

ASJC Scopus subject areas

  • Neuroscience(all)


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