Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura*, Shigeru Miyaki, Hiroyuki Ishitobi, Sho Matsuyama, Tomoyuki Nakasa, Naosuke Kamei, Takayuki Akimoto, Yukihito Higashi, Mitsuo Ochi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

388 Citations (Scopus)


Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

Original languageEnglish
Article number37090
Pages (from-to)1257-1265
Number of pages9
JournalFEBS Letters
Issue number11
Publication statusPublished - 2015 May 8
Externally publishedYes


  • Exosome
  • Mesenchymal stem cell
  • MicroRNA
  • Regeneration
  • Skeletal muscle

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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