Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura; Shigeru Miyaki; Hiroyuki Ishitobi; Sho Matsuyama; Tomoyuki Nakasa; Naosuke Kamei; Takayuki Akimoto; Yukihito Higashi; Mitsuo Ochi

doi:10.1016/j.febslet.2015.03.031

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura^*, Shigeru Miyaki, Hiroyuki Ishitobi, Sho Matsuyama, Tomoyuki Nakasa, Naosuke Kamei, Takayuki Akimoto, Yukihito Higashi, Mitsuo Ochi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

388 Citations (Scopus)

Abstract

Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

Original language	English
Article number	37090
Pages (from-to)	1257-1265
Number of pages	9
Journal	FEBS Letters
Volume	589
Issue number	11
DOIs	https://doi.org/10.1016/j.febslet.2015.03.031
Publication status	Published - 2015 May 8
Externally published	Yes

Keywords

Exosome
Mesenchymal stem cell
MicroRNA
Regeneration
Skeletal muscle

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2015.03.031

Cite this

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title = "Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration",

abstract = "Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.",

keywords = "Exosome, Mesenchymal stem cell, MicroRNA, Regeneration, Skeletal muscle",

author = "Yoshihiro Nakamura and Shigeru Miyaki and Hiroyuki Ishitobi and Sho Matsuyama and Tomoyuki Nakasa and Naosuke Kamei and Takayuki Akimoto and Yukihito Higashi and Mitsuo Ochi",

note = "Funding Information: This project was supported by a MEXT/JSPS KAKENHI Grant-in-Aid for Scientific Research (A) Grant Number 25253089 (M.O.), young scientists (A) Grant Number 24689057 (S.M.), and the Mochida Memorial Foundation for Medical and Pharmaceutical Research (S.M.).",

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month = may,

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doi = "10.1016/j.febslet.2015.03.031",

language = "English",

volume = "589",

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T1 - Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

AU - Nakamura, Yoshihiro

AU - Miyaki, Shigeru

AU - Ishitobi, Hiroyuki

AU - Matsuyama, Sho

AU - Nakasa, Tomoyuki

AU - Kamei, Naosuke

AU - Akimoto, Takayuki

AU - Higashi, Yukihito

AU - Ochi, Mitsuo

N1 - Funding Information: This project was supported by a MEXT/JSPS KAKENHI Grant-in-Aid for Scientific Research (A) Grant Number 25253089 (M.O.), young scientists (A) Grant Number 24689057 (S.M.), and the Mochida Memorial Foundation for Medical and Pharmaceutical Research (S.M.).

PY - 2015/5/8

Y1 - 2015/5/8

N2 - Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

AB - Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

KW - Exosome

KW - Mesenchymal stem cell

KW - MicroRNA

KW - Regeneration

KW - Skeletal muscle

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JO - FEBS Letters

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ER -

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Abstract

Keywords

ASJC Scopus subject areas

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