TY - JOUR
T1 - Metabolic alterations in the peritumoral brain in cases of meningiomas
T2 - 1H-MRS study
AU - Chernov, Mikhail F.
AU - Nakaya, Kotaro
AU - Kasuya, Hidetoshi
AU - Kato, Koichi
AU - Ono, Yuko
AU - Yoshida, Shigetoshi
AU - Nakamura, Ryoichi
AU - Suzuki, Takashi
AU - Muragaki, Yoshihiro
AU - Iseki, Hiroshi
AU - Kubo, Osami
AU - Hori, Tomokatsu
AU - Takakura, Kintomo
N1 - Funding Information:
This work was supported by the Program for Promoting the Establishment of Strategic Research Centers, Special Coordination Funds for Promoting Science and Technology, Ministry of Education, Culture, Sports, Science and Technology (Japan). Partial support was also obtained from Japan Brain Foundation. The authors are thankful to Dr. Craig Gough for helping with manuscript preparation.
PY - 2009/9/15
Y1 - 2009/9/15
N2 - The objective of the present study was metabolic characterization of the peritumoral brain in the vicinity of meningiomas using proton magnetic resonance spectroscopy (1H-MRS). Data of long-echo (TR: 2000 ms, TE: 136 ms) single-voxel spectroscopic investigations were obtained during preoperative examination of 81 patients (19 men and 62 women; mean age, 56.5 years). Twenty-seven neoplasms were disclosed incidentally. Moderate-to-severe peritumoral edema was presented in 20 cases. Invasive growth of the tumor was macroscopically identified during surgery in 35 cases. Analyzed metabolites included N-acetylaspartate (NAA), choline-containing compounds (Cho), mobile lipids (Lip) and lactate (Lac). Compared to distant normal-appearing white matter 1H-MRS of the brain in the vicinity of meningiomas disclosed statistically significant decrease of NAA content (P = 0.0019). Investigated metabolic parameters depended on the presence of invasive tumor growth and prominent peritumoral edema, as well as on the size of the neoplasm, its location, and the patient's age. More severe 1H-MRS-detected peritumoral metabolic abnormalities associated with invasive growth of meningioma might be used for its prediction. The presence of meningioma-related neurological symptoms was mainly determined by the size of the tumor, while might be also associated with lower normalized NAA/Cho ratio and more frequent presence of a Lip peak in the peritumoral brain. In conclusion, decrease of NAA content constitutes the most prominent 1H-MRS-detected brain abnormality in the vicinity of intracranial meningiomas. Peritumoral spectroscopic alterations are determined by a variety of factors, can be predictive for invasive tumor growth and may correspond to presented neurological symptoms.
AB - The objective of the present study was metabolic characterization of the peritumoral brain in the vicinity of meningiomas using proton magnetic resonance spectroscopy (1H-MRS). Data of long-echo (TR: 2000 ms, TE: 136 ms) single-voxel spectroscopic investigations were obtained during preoperative examination of 81 patients (19 men and 62 women; mean age, 56.5 years). Twenty-seven neoplasms were disclosed incidentally. Moderate-to-severe peritumoral edema was presented in 20 cases. Invasive growth of the tumor was macroscopically identified during surgery in 35 cases. Analyzed metabolites included N-acetylaspartate (NAA), choline-containing compounds (Cho), mobile lipids (Lip) and lactate (Lac). Compared to distant normal-appearing white matter 1H-MRS of the brain in the vicinity of meningiomas disclosed statistically significant decrease of NAA content (P = 0.0019). Investigated metabolic parameters depended on the presence of invasive tumor growth and prominent peritumoral edema, as well as on the size of the neoplasm, its location, and the patient's age. More severe 1H-MRS-detected peritumoral metabolic abnormalities associated with invasive growth of meningioma might be used for its prediction. The presence of meningioma-related neurological symptoms was mainly determined by the size of the tumor, while might be also associated with lower normalized NAA/Cho ratio and more frequent presence of a Lip peak in the peritumoral brain. In conclusion, decrease of NAA content constitutes the most prominent 1H-MRS-detected brain abnormality in the vicinity of intracranial meningiomas. Peritumoral spectroscopic alterations are determined by a variety of factors, can be predictive for invasive tumor growth and may correspond to presented neurological symptoms.
KW - Invasive growth
KW - Meningioma
KW - Metabolic alterations
KW - Neurological symptoms
KW - Peritumoral brain edema
KW - Proton magnetic resonance spectroscopy
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U2 - 10.1016/j.jns.2009.05.015
DO - 10.1016/j.jns.2009.05.015
M3 - Article
C2 - 19497588
AN - SCOPUS:67849101654
SN - 0022-510X
VL - 284
SP - 168
EP - 174
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -