Metabolites as clock hands: Estimation of internal body time using blood metabolomics

Hitoshi Iuchi; Rikuhiro G. Yamada; Hiroki R. Ueda

doi:10.1007/978-1-4939-2754-8_15

Metabolites as clock hands: Estimation of internal body time using blood metabolomics

Hitoshi Iuchi, Rikuhiro G. Yamada, Hiroki R. Ueda

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The circadian clock governs body time and regulates many physiological functions including sleep and wake cycles, body temperature, feeding, and hormone secretion. Alignment of drug dosing time to body time can maximize the pharmacological effect and minimize untoward effects. Therefore, a simple and robust method for estimating body time is important for drug efficacy or “chronotherapy”. We previously reported that a metabolite timetable could estimate body time with good accuracy. A metabolite timetable was constructed by profiling metabolites in human and mouse with capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography–mass spectrometry (LC-MS). In this chapter, we describe practical methods to profile and identify oscillating metabolites.

Original language	English
Title of host publication	Neuromethods
Publisher	Humana Press Inc.
Pages	245-254
Number of pages	10
DOIs	https://doi.org/10.1007/978-1-4939-2754-8_15
Publication status	Published - 2016
Externally published	Yes

Publication series

Name	Neuromethods
Volume	105
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Keywords

Capillary electrophoresis–mass spectrometry
Chronotherapy
Circadian
Liquid chromatography–mass spectrometry
Metabolomics

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4939-2754-8_15

Cite this

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title = "Metabolites as clock hands: Estimation of internal body time using blood metabolomics",

abstract = "The circadian clock governs body time and regulates many physiological functions including sleep and wake cycles, body temperature, feeding, and hormone secretion. Alignment of drug dosing time to body time can maximize the pharmacological effect and minimize untoward effects. Therefore, a simple and robust method for estimating body time is important for drug efficacy or “chronotherapy”. We previously reported that a metabolite timetable could estimate body time with good accuracy. A metabolite timetable was constructed by profiling metabolites in human and mouse with capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography–mass spectrometry (LC-MS). In this chapter, we describe practical methods to profile and identify oscillating metabolites.",

keywords = "Capillary electrophoresis–mass spectrometry, Chronotherapy, Circadian, Liquid chromatography–mass spectrometry, Metabolomics",

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language = "English",

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T2 - Estimation of internal body time using blood metabolomics

AU - Iuchi, Hitoshi

AU - Yamada, Rikuhiro G.

AU - Ueda, Hiroki R.

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PY - 2016

Y1 - 2016

N2 - The circadian clock governs body time and regulates many physiological functions including sleep and wake cycles, body temperature, feeding, and hormone secretion. Alignment of drug dosing time to body time can maximize the pharmacological effect and minimize untoward effects. Therefore, a simple and robust method for estimating body time is important for drug efficacy or “chronotherapy”. We previously reported that a metabolite timetable could estimate body time with good accuracy. A metabolite timetable was constructed by profiling metabolites in human and mouse with capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography–mass spectrometry (LC-MS). In this chapter, we describe practical methods to profile and identify oscillating metabolites.

AB - The circadian clock governs body time and regulates many physiological functions including sleep and wake cycles, body temperature, feeding, and hormone secretion. Alignment of drug dosing time to body time can maximize the pharmacological effect and minimize untoward effects. Therefore, a simple and robust method for estimating body time is important for drug efficacy or “chronotherapy”. We previously reported that a metabolite timetable could estimate body time with good accuracy. A metabolite timetable was constructed by profiling metabolites in human and mouse with capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography–mass spectrometry (LC-MS). In this chapter, we describe practical methods to profile and identify oscillating metabolites.

KW - Capillary electrophoresis–mass spectrometry

KW - Chronotherapy

KW - Circadian

KW - Liquid chromatography–mass spectrometry

KW - Metabolomics

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ER -

Metabolites as clock hands: Estimation of internal body time using blood metabolomics

Abstract

Publication series

Keywords

ASJC Scopus subject areas

UN SDGs

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