Metabolomics analysis of umbilical cord blood clarifies changes in saccharides associated with delivery method

Fusako Hashimoto, Shin Nishiumi, Osamu Miyake, Hitomi Takeichi, Mari Chitose, Hiromi Ohtsubo, Shingo Ishimori, Takeshi Ninchoji, Yuya Hashimura, Hiroshi Kaito, Naoya Morisada, Ichiro Morioka, Hideoki Fukuoka, Masaru Yoshida, Kazumoto Iijima*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Background: A metabolomic approach using umbilical cord blood from infants at birth has not been studied widely yet. Aim: We examined changes in metabolite levels in umbilical cord blood at birth via gas chromatography/mass spectrometry (GC/MS)-based metabolomics, with the aim of achieving a detailed understanding of fetal stress during labor. Study design: All procedures were reviewed and approved by the Institutional Review Board of Kobe University School of Medicine. This was a cohort study of pregnant women based in Palmore Hospital, which is located in an urban area of Japan, and was carried out between December 2010 and May 2011. Subject: Umbilical cord arterial blood samples were obtained from 41 infants immediately after delivery. Outcome measures: Metabolites in the blood samples were measured using GC/MS to investigate whether the delivery method (spontaneous onset of labor, induction of labor or elective cesarean section) affected the metabolite profile in umbilical cord blood. Results: Elective cesarean section without labor led to lower levels of isoleucine, fructose, mannose, glucose, allose, glucuronic acid, inositol and cysteine in comparison with vaginal delivery following spontaneous labor and without medication. Conclusion: It is proposed that the stress associated with labor be involved in alterations in the levels of metabolites, particularly saccharides such as glucose, in umbilical cord blood.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalEarly Human Development
Issue number5
Publication statusPublished - 2013 May


  • Allose
  • Fructose
  • Glucose
  • Mannose

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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