Microbioassay of nystatin with a yeast electrode

Isao Karube*, Tadashi Matsunaga, Shuichi Suzuki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


Microbioassay of nystatin is achieved with an electrode composed of a yeast membrane and an oxygen electrode, based on the inhibitory action of the antibiotic on the respiration of the yeast. A linear relationship is obtained between the rate of current increase and the potency of nystatin. The minimum measurable nystatin concentration is 0.5 unit ml-1.The assay takes less than l h; the standard deviation is 1.2 unit ml-1 at the 27 USP unit ml-1 level.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalAnalytica Chimica Acta
Issue number1
Publication statusPublished - 1979 Aug 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry


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