Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini*, Hirokazu Kaji

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

Original languageEnglish
Pages (from-to)1699-1705
Number of pages7
JournalAdvanced Materials
Issue number11
Publication statusPublished - 2014 Mar 19


  • cell delivery
  • magnetic nanoparticles (MNP)
  • retinal pigment epithelium (RPE)
  • tight junctions
  • ultrathin films (nanosheets)

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Medicine(all)


Dive into the research topics of 'Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer'. Together they form a unique fingerprint.

Cite this