Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

Toshinori Fujie; Yoshihiro Mori; Shuntaro Ito; Matsuhiko Nishizawa; Hojae Bae; Nobuhiro Nagai; Hideyuki Onami; Toshiaki Abe; Ali Khademhosseini; Hirokazu Kaji

doi:10.1002/adma.201304183

Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini^*, Hirokazu Kaji

^*Corresponding author for this work

Waseda Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

Original language	English
Pages (from-to)	1699-1705
Number of pages	7
Journal	Advanced Materials
Volume	26
Issue number	11
DOIs	https://doi.org/10.1002/adma.201304183
Publication status	Published - 2014 Mar 19

Keywords

cell delivery
magnetic nanoparticles (MNP)
retinal pigment epithelium (RPE)
tight junctions
ultrathin films (nanosheets)

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Medicine(all)

Access to Document

10.1002/adma.201304183

Cite this

@article{cb97c8f28e814e3fbe6027d4cd7a6071,

title = "Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer",

abstract = "Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.",

keywords = "cell delivery, magnetic nanoparticles (MNP), retinal pigment epithelium (RPE), tight junctions, ultrathin films (nanosheets)",

author = "Toshinori Fujie and Yoshihiro Mori and Shuntaro Ito and Matsuhiko Nishizawa and Hojae Bae and Nobuhiro Nagai and Hideyuki Onami and Toshiaki Abe and Ali Khademhosseini and Hirokazu Kaji",

year = "2014",

month = mar,

day = "19",

doi = "10.1002/adma.201304183",

language = "English",

volume = "26",

pages = "1699--1705",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "11",

}

TY - JOUR

T1 - Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

AU - Fujie, Toshinori

AU - Mori, Yoshihiro

AU - Ito, Shuntaro

AU - Nishizawa, Matsuhiko

AU - Bae, Hojae

AU - Nagai, Nobuhiro

AU - Onami, Hideyuki

AU - Abe, Toshiaki

AU - Khademhosseini, Ali

AU - Kaji, Hirokazu

PY - 2014/3/19

Y1 - 2014/3/19

N2 - Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

AB - Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

KW - cell delivery

KW - magnetic nanoparticles (MNP)

KW - retinal pigment epithelium (RPE)

KW - tight junctions

KW - ultrathin films (nanosheets)

UR - http://www.scopus.com/inward/record.url?scp=84896402423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896402423&partnerID=8YFLogxK

U2 - 10.1002/adma.201304183

DO - 10.1002/adma.201304183

M3 - Article

C2 - 24307219

AN - SCOPUS:84896402423

SN - 0935-9648

VL - 26

SP - 1699

EP - 1705

JO - Advanced Materials

JF - Advanced Materials

IS - 11

ER -

Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this