Moderate physical exercise induces the oxidation of human blood protein thiols

Takayo Inayama; Jun Oka; Misato Kashiba; Makoto Saito; Mitsuru Higuchi; Keizo Umegaki; Yorihiro Yamamoto; Mitsuo Matsuda

doi:10.1016/S0024-3205(02)01490-X

Moderate physical exercise induces the oxidation of human blood protein thiols

Takayo Inayama^*, Jun Oka, Misato Kashiba, Makoto Saito, Mitsuru Higuchi, Keizo Umegaki, Yorihiro Yamamoto, Mitsuo Matsuda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Exercise is known to induce the oxidation of blood low-molecular-weight (LMW) thiols such as reduced glutathione (GSH). We previously reported that full-marathon running induced a decrease in human plasma levels of protein-bound sulfhydryl groups (p-SHs). Moderate exercise, a 30-min running at the intensity of the individual ventilatory threshold, performed by untrained healthy females caused a significant decrease in erythrocyte levels of p-SHs (mostly hemoglobin cysteine residues) and LMW thiols, but their levels returned to each baseline by 2 h. No significant change in plasma LMW thiols was observed. However, plasma levels of p-SHs significantly decreased after running and remained unchanged after 24 h. These results suggest that moderate exercise causes the oxidation of blood thiols, especially protein-bound thiols.

Original language	English
Pages (from-to)	2039-2046
Number of pages	8
Journal	Life Sciences
Volume	70
Issue number	17
DOIs	https://doi.org/10.1016/S0024-3205(02)01490-X
Publication status	Published - 2002 Mar 15
Externally published	Yes

Keywords

Erythrocytes
Glutathione
Moderate physical exercise
Oxidative stress
Sulfhydryl compounds

ASJC Scopus subject areas

Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0024-3205(02)01490-X

Cite this

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title = "Moderate physical exercise induces the oxidation of human blood protein thiols",

abstract = "Exercise is known to induce the oxidation of blood low-molecular-weight (LMW) thiols such as reduced glutathione (GSH). We previously reported that full-marathon running induced a decrease in human plasma levels of protein-bound sulfhydryl groups (p-SHs). Moderate exercise, a 30-min running at the intensity of the individual ventilatory threshold, performed by untrained healthy females caused a significant decrease in erythrocyte levels of p-SHs (mostly hemoglobin cysteine residues) and LMW thiols, but their levels returned to each baseline by 2 h. No significant change in plasma LMW thiols was observed. However, plasma levels of p-SHs significantly decreased after running and remained unchanged after 24 h. These results suggest that moderate exercise causes the oxidation of blood thiols, especially protein-bound thiols.",

keywords = "Erythrocytes, Glutathione, Moderate physical exercise, Oxidative stress, Sulfhydryl compounds",

author = "Takayo Inayama and Jun Oka and Misato Kashiba and Makoto Saito and Mitsuru Higuchi and Keizo Umegaki and Yorihiro Yamamoto and Mitsuo Matsuda",

year = "2002",

month = mar,

day = "15",

doi = "10.1016/S0024-3205(02)01490-X",

language = "English",

volume = "70",

pages = "2039--2046",

journal = "Life Sciences",

issn = "0024-3205",

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number = "17",

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TY - JOUR

T1 - Moderate physical exercise induces the oxidation of human blood protein thiols

AU - Inayama, Takayo

AU - Oka, Jun

AU - Kashiba, Misato

AU - Saito, Makoto

AU - Higuchi, Mitsuru

AU - Umegaki, Keizo

AU - Yamamoto, Yorihiro

AU - Matsuda, Mitsuo

PY - 2002/3/15

Y1 - 2002/3/15

N2 - Exercise is known to induce the oxidation of blood low-molecular-weight (LMW) thiols such as reduced glutathione (GSH). We previously reported that full-marathon running induced a decrease in human plasma levels of protein-bound sulfhydryl groups (p-SHs). Moderate exercise, a 30-min running at the intensity of the individual ventilatory threshold, performed by untrained healthy females caused a significant decrease in erythrocyte levels of p-SHs (mostly hemoglobin cysteine residues) and LMW thiols, but their levels returned to each baseline by 2 h. No significant change in plasma LMW thiols was observed. However, plasma levels of p-SHs significantly decreased after running and remained unchanged after 24 h. These results suggest that moderate exercise causes the oxidation of blood thiols, especially protein-bound thiols.

AB - Exercise is known to induce the oxidation of blood low-molecular-weight (LMW) thiols such as reduced glutathione (GSH). We previously reported that full-marathon running induced a decrease in human plasma levels of protein-bound sulfhydryl groups (p-SHs). Moderate exercise, a 30-min running at the intensity of the individual ventilatory threshold, performed by untrained healthy females caused a significant decrease in erythrocyte levels of p-SHs (mostly hemoglobin cysteine residues) and LMW thiols, but their levels returned to each baseline by 2 h. No significant change in plasma LMW thiols was observed. However, plasma levels of p-SHs significantly decreased after running and remained unchanged after 24 h. These results suggest that moderate exercise causes the oxidation of blood thiols, especially protein-bound thiols.

KW - Erythrocytes

KW - Glutathione

KW - Moderate physical exercise

KW - Oxidative stress

KW - Sulfhydryl compounds

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U2 - 10.1016/S0024-3205(02)01490-X

DO - 10.1016/S0024-3205(02)01490-X

M3 - Article

C2 - 12148696

AN - SCOPUS:0037087146

SN - 0024-3205

VL - 70

SP - 2039

EP - 2046

JO - Life Sciences

JF - Life Sciences

IS - 17

ER -

Moderate physical exercise induces the oxidation of human blood protein thiols

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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