Moderate physical exercise induces the oxidation of human blood protein thiols

Takayo Inayama*, Jun Oka, Misato Kashiba, Makoto Saito, Mitsuru Higuchi, Keizo Umegaki, Yorihiro Yamamoto, Mitsuo Matsuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Exercise is known to induce the oxidation of blood low-molecular-weight (LMW) thiols such as reduced glutathione (GSH). We previously reported that full-marathon running induced a decrease in human plasma levels of protein-bound sulfhydryl groups (p-SHs). Moderate exercise, a 30-min running at the intensity of the individual ventilatory threshold, performed by untrained healthy females caused a significant decrease in erythrocyte levels of p-SHs (mostly hemoglobin cysteine residues) and LMW thiols, but their levels returned to each baseline by 2 h. No significant change in plasma LMW thiols was observed. However, plasma levels of p-SHs significantly decreased after running and remained unchanged after 24 h. These results suggest that moderate exercise causes the oxidation of blood thiols, especially protein-bound thiols.

Original languageEnglish
Pages (from-to)2039-2046
Number of pages8
JournalLife Sciences
Issue number17
Publication statusPublished - 2002 Mar 15
Externally publishedYes


  • Erythrocytes
  • Glutathione
  • Moderate physical exercise
  • Oxidative stress
  • Sulfhydryl compounds

ASJC Scopus subject areas

  • Pharmacology


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