Moderate regular exercise increases basal production of nitric oxide in elderly women

Seiji Maeda*, Takumi Tanabe, Takeshi Otsuki, Jun Sugawara, Motoyuki Iemitsu, Takashi Miyauchi, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

121 Citations (Scopus)


Vascular endothelial cells produce nitric oxide (NO), which is a potent vasodilator substance and is thought to have antiatherosclerotic properties. Therefore, it has also been proposed that NO may be useful to regulate vascular tonus and prevent progression of atherosclerosis. On the other hand, NO activity reduces with aging. We previously reported that the plasma nitrite/nitrate (NOx: the stable end product of NO) concentration was significantly increased by intense aerobic exercise training in healthy young humans. We hypothesized that lifestyle modification (e.g., even mild regular exercise training) can increase NO production in previously sedentary older humans. We measured the plasma NOx concentration before and after a mild aerobic exercise training regimen (cycling on a leg ergometer at 80% ventilatory threshold for 30 min, 5 days/week) for 3 months in elderly women. In addition, we assessed the plasma concentration of cyclic guanosine monophosphate (cGMP), a second messenger of NO, in the same samples. The individual ventilatory threshold increased significantly after the 3-month exercise training. The blood pressure at rest significantly decreased after exercise training. These results suggest that the 3-month exercise training in the older women produced favorable physiological effects. The plasma concentration of NOx significantly increased by the exercise training, and the plasma concentration of cGMP also increased by the exercise training. The present study suggests that even a mild regular aerobic-endurance exercise increases NO production in previously sedentary older humans, which may have beneficial effect (i.e., antlhypertensive and antiatherosclerotic effects by endogenous NO) on the cardiovascular system.

Original languageEnglish
Pages (from-to)947-953
Number of pages7
JournalHypertension Research
Issue number12
Publication statusPublished - 2004 Dec
Externally publishedYes


  • Aging
  • Cyclic guanosine monophosphate
  • Exercise training
  • Lifestyle
  • Nitric oxide

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Moderate regular exercise increases basal production of nitric oxide in elderly women'. Together they form a unique fingerprint.

Cite this