Molecular biological diagnosis

N. Ikeda*, H. Shibuya, H. Nakamura, T. Hirano, M. Kakihana, K. Furukawa, N. Kawate, C. Konaka, H. Kato

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Biological behavior of lung cancer was evaluated by basic study. Malignancy Associated Change is the concept that the nuclear features of normal cells in the vicinity of cancer show subtle morphological difference from those of healthy individuals. The difference was recognized by high resolution cytometry and the expression of MAC cells was correlated with the degree of abnormality of chest diseases. Comparative genomic hybridization and fluorescence in situ hybridization were performed to investigate genetic abnormality of. Multiple genetic abnormalities and chromosomal instability showed poor prognosis. Two dimensional electrophoresis was employed to detect the expression of the specific protein of lung cancer. TAO2 was proved to be specific to well differentiated adenocarcinoma. Also, metabolic analysis will be employed for cell analysis.

Original languageEnglish
Pages (from-to)1074-1081
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number5
Publication statusPublished - 2000 May
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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