Molecular design of artificial hydrolytic nucleases and ribonucleases.

M. Komiyama*, T. Inokawa, T. Shiiba, N. Takeda, K. Yoshinari, M. Yashiro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.

Original languageEnglish
Pages (from-to)197-198
Number of pages2
JournalNucleic acids symposium series
Issue number29
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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