Molecular design of artificial hydrolytic nucleases and ribonucleases.

M. Komiyama; T. Inokawa; T. Shiiba; N. Takeda; K. Yoshinari; M. Yashiro

Molecular design of artificial hydrolytic nucleases and ribonucleases.

M. Komiyama^*, T. Inokawa, T. Shiiba, N. Takeda, K. Yoshinari, M. Yashiro

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.

Original language	English
Pages (from-to)	197-198
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	29
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Cite this

@article{c7796148891c4a2a9279ae6d531e2933,

title = "Molecular design of artificial hydrolytic nucleases and ribonucleases.",

abstract = "Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.",

author = "M. Komiyama and T. Inokawa and T. Shiiba and N. Takeda and K. Yoshinari and M. Yashiro",

year = "1993",

language = "English",

pages = "197--198",

journal = "Nucleic acids symposium series",

issn = "0261-3166",

publisher = "Information Retrieval",

number = "29",

}

TY - JOUR

T1 - Molecular design of artificial hydrolytic nucleases and ribonucleases.

AU - Komiyama, M.

AU - Inokawa, T.

AU - Shiiba, T.

AU - Takeda, N.

AU - Yoshinari, K.

AU - Yashiro, M.

PY - 1993

Y1 - 1993

N2 - Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.

AB - Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.

UR - http://www.scopus.com/inward/record.url?scp=0027479964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027479964&partnerID=8YFLogxK

M3 - Article

C2 - 8247767

AN - SCOPUS:0027479964

SN - 0261-3166

SP - 197

EP - 198

JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

IS - 29

ER -

Molecular design of artificial hydrolytic nucleases and ribonucleases.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this