Molecular Mechanisms of Skeletal Muscle Hypertrophy

Stefano Schiaffino*, Carlo Reggiani, Takayuki Akimoto, Bert Blaauw

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

61 Citations (Scopus)


Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and by mechanical signals mediating the effect of resistance exercise. Muscle growth during hypertrophy is controlled at the translational level, through the stimulation of protein synthesis, and at the transcriptional level, through the activation of ribosomal RNAs and muscle-specific genes. mTORC1 has a central role in the regulation of both protein synthesis and ribosomal biogenesis. Several transcription factors and co-activators, including MEF2, SRF, PGC-1a4, and YAP promote the growth of the myofibers. Satellite cell proliferation and fusion is involved in some but not all muscle hypertrophy models.

Original languageEnglish
Pages (from-to)169-183
Number of pages15
JournalJournal of Neuromuscular Diseases
Issue number2
Publication statusPublished - 2021


  • MEF2
  • SRF
  • Skeletal muscle
  • mTOR
  • muscle hypertrophy
  • ribosomal biogenesis
  • transcriptional control
  • translational control

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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