Multiple purpose simulator using a natural porcine mitral valve

Makoto Arita*, Sumihiro Tono, Hitoshi Kasegawa, Mitsuo Umezu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


An in vitro pulsatile simulator with a porcine mitral valve was developed in order to simulate physiologic and diseased mitral valve conditions. Evaluation of these conditions was conducted from a hydrodynamic and annulus behavior point of view. We found it possible to simulate mild "mitral valve prolapse" and to obtain quantitative data related to the condition. The diseased condition produced a 40% greater regurgitant volume than that observed under the normal condition (p < 0.0001). Regarding the leakage volume, the diseased condition exhibited about 2.6 times more leakage than the normal condition. The mitral valve simulator proposed in this study is considered fairly stable with respect to both hemodynamics and the behavior of the annulus, and it is an adequate simulator for modeling various types of normal and diseased mitral valve conditions.

Original languageEnglish
Pages (from-to)350-356
Number of pages7
JournalAsian Cardiovascular and Thoracic Annals
Issue number4
Publication statusPublished - 2004 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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