Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation

Satoshi Hayakawa*, Tomoyuki Fujikawa, Hideoki Fukuoka, Fumihisa Chisima, Miki Karasaki-Suzuki, Emika Ohkoshi, Hiroyuki Ohi, Tom Kiyoshi Fujii, Meijin Tochigi, Kazuo Satoh, Takako Shimizu, Susumu Nishinarita, Norimichi Nemoto, Isamu Sakurai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


It has been proposed that immune responses in mammalian normal pregnancy are Th2-like, thereby protecting the fetus and placenta from being rejected. Administration of exogenous Th1 cytokines into pregnant mice is reported to induce feto-placental resorption. However, the effects of exogenous Th2 cytokines and Th2 directed responses in pregnant animals have not been well studied. In this study, we examined IL-4 and IL-12, which play decisive roles in the development of Th2 and Th1 responses, respectively, in the induction of fetal resorption and development of experimental pre-eclampsia. Transfer of either IL-4 and/or IL-12 stimulated splenocytes from BALB/C virgin female mice into BALB/C pregnant mice mated with either C57BL/6 or BALB/C male mice resulted in fetal resorption and glomerular nephritis associated with hypertension and proteinuria. In mice treated with IL-12 stimulated splenocytes, fatty liver degeneration associated with bile retention was observed. These results indicate that both excessive Th1 and Th2 activation contribute to the development of fetal resorption and pre-eclampsia, but that Th1 is critical to the development of liver degeneration. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)121-138
Number of pages18
JournalJournal of Reproductive Immunology
Issue number2
Publication statusPublished - 2000 Jul
Externally publishedYes


  • Fetal resorption
  • Pre-eclampsia
  • Th1/Th2

ASJC Scopus subject areas

  • Immunology
  • Reproductive Medicine


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