Muscarinic receptor occupancy by biperiden in living human brain

Yasuhiko Sudo*, Tetsuya Suhara, Kazutoshi Suzuki, Yoshiro Okubo, Kyosan Yoshikawa, Sunao Uchida, Takeshi Sassa, Takashi Okauchi, Yasuhito Sasaki, Masaaki Matsushita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Anticholinergic drug is often used to treat extrapyramidal symptoms. We measured muscarinic cholinergic receptor (mAchR) occupancy by the oral administration of biperiden in eight healthy subjects using positron emission tomography (PET) and [11C]N-methyl-4-piperidylbenzilate (NMPB). After the baseline scan each subject underwent one or two post-dose PET scans, mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner.

Original languageEnglish
JournalLife Sciences
Issue number8
Publication statusPublished - 1999 Jan 15
Externally publishedYes


  • Biperiden
  • Human
  • Muscarinic cholinergic receptor
  • Positron emission tomography

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Muscarinic receptor occupancy by biperiden in living human brain'. Together they form a unique fingerprint.

Cite this