TY - GEN
T1 - Muscle oxygen dynamics during cycling exercise in angina pectoris patients
AU - Takagi, Shun
AU - Murase, Norio
AU - Kime, Ryotaro
AU - Niwayama, Masatsugu
AU - Osada, Takuya
AU - Katsumura, Toshihito
PY - 2016
Y1 - 2016
N2 - Muscle O2 dynamics during ramp cycling exercise were compared between angina pectoris patients (AP; n = 7, age: 73 ± 6 years) after coronary artery bypass grafting and age-, height-, and body weight-matched elderly control subjects (CON; n = 7, age: 74 ± 8 years). Muscle O2 saturation (SmO2) and relative change in deoxygenated (Δdeoxy-Hb) and total hemoglobin concentration (Δtotal-Hb) were measured continuously during exercise in the vastus lateralis (VL) by near infrared spatial resolved spectroscopy. Pulmonary O2 uptake (VO2) was also monitored throughout exercise to determine peak VO2. In AP, SmO2 was significantly higher, and Δdeoxy-Hb was significantly lower during exercise, compared to CON. In all subjects, ΔSmO2 (values at peak exercise minus values at resting) was negatively correlated to peak VO2 (r = −0.52, p < 0.05), and Δdeoxy-Hb at peak exercise tended to be negatively associated with peak VO2 (r = 0.48, p = 0.07). Blunted skeletal muscle deoxygenation response was observed in AP patients, which may be related to lower aerobic capacity in AP patients.
AB - Muscle O2 dynamics during ramp cycling exercise were compared between angina pectoris patients (AP; n = 7, age: 73 ± 6 years) after coronary artery bypass grafting and age-, height-, and body weight-matched elderly control subjects (CON; n = 7, age: 74 ± 8 years). Muscle O2 saturation (SmO2) and relative change in deoxygenated (Δdeoxy-Hb) and total hemoglobin concentration (Δtotal-Hb) were measured continuously during exercise in the vastus lateralis (VL) by near infrared spatial resolved spectroscopy. Pulmonary O2 uptake (VO2) was also monitored throughout exercise to determine peak VO2. In AP, SmO2 was significantly higher, and Δdeoxy-Hb was significantly lower during exercise, compared to CON. In all subjects, ΔSmO2 (values at peak exercise minus values at resting) was negatively correlated to peak VO2 (r = −0.52, p < 0.05), and Δdeoxy-Hb at peak exercise tended to be negatively associated with peak VO2 (r = 0.48, p = 0.07). Blunted skeletal muscle deoxygenation response was observed in AP patients, which may be related to lower aerobic capacity in AP patients.
KW - Aerobic capacity
KW - Blood volume
KW - Ischemic heart disease
KW - Muscle oxygen saturation
KW - Near infrared spectroscopy
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U2 - 10.1007/978-3-319-38810-6_39
DO - 10.1007/978-3-319-38810-6_39
M3 - Conference contribution
AN - SCOPUS:84984815313
SN - 9783319388083
VL - 923
T3 - Advances in Experimental Medicine and Biology
SP - 291
EP - 297
BT - Oxygen Transport to Tissue XXXVIII
PB - Springer New York LLC
T2 - 43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015
Y2 - 11 July 2015 through 16 July 2015
ER -