Myosin V walks by lever action and Bownian motion

Katsuyuki Shiroguchi, Kazuhiko Kinosita*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    109 Citations (Scopus)


    Myosin V is a molecular motor that moves cargo along actin filaments. Its two heads, each attached to a long and relatively stiff neck, move alternately forward in a "hand-over-hand" fashion. To observe under a microscope how the necks move, we attached a micrometer-sized rod to one of the necks. The leading neck swings undirectionally forward, whereas the trailing neck, once lifted, undergoes extensive Brownian rotation in all directions before landing on a she ahead of the leading head. The neck-neck joint is essentially free, and the neck motion supports a mechanism where the active swing of the leading neck biases the random motion of the lifted head to let it eventually land on a forward site.

    Original languageEnglish
    Pages (from-to)1208-1212
    Number of pages5
    Issue number5828
    Publication statusPublished - 2007 May 25

    ASJC Scopus subject areas

    • General


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