N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Yukiko Nisikawa; Takao Shimazoe; Shigenobu Shibata; Shigenori Watanabe

doi:10.1016/S0006-8993(97)01177-3

N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Yukiko Nisikawa, Takao Shimazoe^*, Shigenobu Shibata, Shigenori Watanabe

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

Original language	English
Pages (from-to)	303-305
Number of pages	3
Journal	Brain Research
Volume	782
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(97)01177-3
Publication status	Published - 1998 Jan 26

Keywords

Long-term potentiation
N-Methyl-D-aspartate receptor
NMDA receptor
Suprachiasmatic nucleus
Synaptic potential

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(97)01177-3

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title = "N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro",

abstract = "Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.",

keywords = "Long-term potentiation, N-Methyl-D-aspartate receptor, NMDA receptor, Suprachiasmatic nucleus, Synaptic potential",

author = "Yukiko Nisikawa and Takao Shimazoe and Shigenobu Shibata and Shigenori Watanabe",

year = "1998",

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journal = "Brain Research",

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T1 - N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

AU - Nisikawa, Yukiko

AU - Shimazoe, Takao

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

PY - 1998/1/26

Y1 - 1998/1/26

N2 - Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

AB - Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

KW - Long-term potentiation

KW - N-Methyl-D-aspartate receptor

KW - NMDA receptor

KW - Suprachiasmatic nucleus

KW - Synaptic potential

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AN - SCOPUS:0032567701

SN - 0006-8993

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SP - 303

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JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Abstract

Keywords

ASJC Scopus subject areas

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