Navigating the folding energy landscape of green fluorescent protein

Morten Bertz*, Andrea Kunfermann, Matthias Rief

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


The directed application of force to different points on the surface of the green fluorescent protein (GFP) makes it possible to shift between two different pathways with distinct unfolding intermediates. One pathway resembles a "folding-like" pathway, whereas the other may play a role during processes such as import through a pore. The picture shows the energy landscape of GFP with intermediates and pathways. (Figure Presented)

Original languageEnglish
Pages (from-to)8192-8195
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number43
Publication statusPublished - 2008 Oct 13
Externally publishedYes


  • Protein engineering
  • Protein folding
  • Protein structures
  • Scanning probe microscopy
  • Single-molecule studies

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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