Nazumamide A, a thrombin-inhibitory Tetrapeptide, from a marine sponge, theonella sp.

Nobuhiro Fusetani; Youichi Nakao; Shigeki Matsunaga

doi:10.1016/0040-4039(91)85043-5

Nazumamide A, a thrombin-inhibitory Tetrapeptide, from a marine sponge, theonella sp.

Nobuhiro Fusetani^*, Youichi Nakao, Shigeki Matsunaga

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Nazumamide A, a thrombin-inhibiting linear @Tetrapeptide, was isolated from a marine sponge, Theonella sp. The structure of nazumamide A was determined by interpretation of 2D NMR data and by chemical degradation as 2,5-dihydroxybenzoyl-l-arginyl-l-prolyl-l-isoleucyl-l-α-aminobutyric acid.

Original language	English
Pages (from-to)	7073-7074
Number of pages	2
Journal	Tetrahedron Letters
Volume	32
Issue number	48
DOIs	https://doi.org/10.1016/0040-4039(91)85043-5
Publication status	Published - 1991 Nov 25
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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@article{27daa50082104735a98f398324321d2b,

title = "Nazumamide A, a thrombin-inhibitory Tetrapeptide, from a marine sponge, theonella sp.",

abstract = "Nazumamide A, a thrombin-inhibiting linear @Tetrapeptide, was isolated from a marine sponge, Theonella sp. The structure of nazumamide A was determined by interpretation of 2D NMR data and by chemical degradation as 2,5-dihydroxybenzoyl-l-arginyl-l-prolyl-l-isoleucyl-l-α-aminobutyric acid.",

author = "Nobuhiro Fusetani and Youichi Nakao and Shigeki Matsunaga",

note = "Funding Information: dihydroxybenzoate terminus. The acid is known as, inter alia, a constituent of Penicillium griseofalvum.lo Acknowledgment: We thank Professor P. J. Scheuer, the University of Hawaii, for editorial comments. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.",

year = "1991",

month = nov,

day = "25",

doi = "10.1016/0040-4039(91)85043-5",

language = "English",

volume = "32",

pages = "7073--7074",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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number = "48",

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TY - JOUR

T1 - Nazumamide A, a thrombin-inhibitory Tetrapeptide, from a marine sponge, theonella sp.

AU - Fusetani, Nobuhiro

AU - Nakao, Youichi

AU - Matsunaga, Shigeki

N1 - Funding Information: dihydroxybenzoate terminus. The acid is known as, inter alia, a constituent of Penicillium griseofalvum.lo Acknowledgment: We thank Professor P. J. Scheuer, the University of Hawaii, for editorial comments. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

PY - 1991/11/25

Y1 - 1991/11/25

N2 - Nazumamide A, a thrombin-inhibiting linear @Tetrapeptide, was isolated from a marine sponge, Theonella sp. The structure of nazumamide A was determined by interpretation of 2D NMR data and by chemical degradation as 2,5-dihydroxybenzoyl-l-arginyl-l-prolyl-l-isoleucyl-l-α-aminobutyric acid.

AB - Nazumamide A, a thrombin-inhibiting linear @Tetrapeptide, was isolated from a marine sponge, Theonella sp. The structure of nazumamide A was determined by interpretation of 2D NMR data and by chemical degradation as 2,5-dihydroxybenzoyl-l-arginyl-l-prolyl-l-isoleucyl-l-α-aminobutyric acid.

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U2 - 10.1016/0040-4039(91)85043-5

DO - 10.1016/0040-4039(91)85043-5

M3 - Article

AN - SCOPUS:0025934023

SN - 0040-4039

VL - 32

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EP - 7074

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 48

ER -

Nazumamide A, a thrombin-inhibitory Tetrapeptide, from a marine sponge, theonella sp.

Abstract

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