Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates

Alberto Bonisoli, Attilio Marino, Gianni Ciofani, Francesco Greco

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.

Original languageEnglish
Title of host publicationOrganic Bioelectronics - Materials, Processes and Applications
PublisherMaterials Research Society
Number of pages6
ISBN (Electronic)9781510826489
Publication statusPublished - 2015
Externally publishedYes
Event2015 MRS Spring Meeting - San Francisco, United States
Duration: 2015 Apr 62015 Apr 10


Other2015 MRS Spring Meeting
Country/TerritoryUnited States
CitySan Francisco

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


Dive into the research topics of 'Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates'. Together they form a unique fingerprint.

Cite this