Neurosteroid biosynthesis in the brain of amphibians

Hubert Vaudry*, Jean Luc Do Rego, Delphine Burel, Van Luu-The, Georges Pelletier, David Vaudry, Kazuyoshi Tsutsui

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)


    Amphibians have been widely used to investigate the synthesis of biologically active steroids in the brain and the regulation of neurosteroid production by neurotransmitters and neuropeptides. The aim of the present review is to summarize the current knowl- edge regarding the neuroanatomical distribution and biochemical activity of steroidogenic enzymes in the brain of anurans and urodeles. The data accumulated over the past two decades demonstrate that discrete populations of neurons and/or glial cells in the frog and newt brains express the major steroidogenic enzymes and are able to synthesize de novo a number of neurosteroids from cholesterol/pregnenolone. Since neurosteroidogen- esis has been conserved during evolution from amphibians to mammals, it appears that neurosteroids must play important physiological functions in the central nervous system of vertebrates.

    Original languageEnglish
    Article numberArticle 79
    JournalFrontiers in Endocrinology
    Issue numberNOV
    Publication statusPublished - 2011


    • Amphibians
    • Brain
    • Neurosteroids
    • Steroidogenic enzymes

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism


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