New implications of memory mechanisms for Alzheimer's disease.

R. Etcheberrigaray; E. Ito; K. Oka; B. Tofel-Grehl; G. E. Gibson; D. L. Alkon

New implications of memory mechanisms for Alzheimer's disease.

R. Etcheberrigaray^*
, E. Ito
, K. Oka
, B. Tofel-Grehl
, G. E. Gibson
, D. L. Alkon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K⁺ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

Original language	English
Pages (from-to)	S7-S10
Journal	Neuroscience Research Communications
Volume	12
Issue number	SUPPL. 1
Publication status	Published - 1993
Externally published	Yes

Keywords

Alzheimer's disease
Memory
Potassium channels

ASJC Scopus subject areas

General Neuroscience

Cite this

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title = "New implications of memory mechanisms for Alzheimer's disease.",

abstract = "Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.",

keywords = "Alzheimer's disease, Memory, Potassium channels",

author = "R. Etcheberrigaray and E. Ito and K. Oka and B. Tofel-Grehl and Gibson, \{G. E.\} and Alkon, \{D. L.\}",

year = "1993",

language = "English",

volume = "12",

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journal = "Neuroscience Research Communications",

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T1 - New implications of memory mechanisms for Alzheimer's disease.

AU - Etcheberrigaray, R.

AU - Ito, E.

AU - Oka, K.

AU - Tofel-Grehl, B.

AU - Gibson, G. E.

AU - Alkon, D. L.

PY - 1993

Y1 - 1993

N2 - Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

AB - Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

KW - Alzheimer's disease

KW - Memory

KW - Potassium channels

UR - https://www.scopus.com/pages/publications/0027203249

UR - https://www.scopus.com/pages/publications/0027203249#tab=citedBy

M3 - Article

AN - SCOPUS:0027203249

SN - 0893-6609

VL - 12

SP - S7-S10

JO - Neuroscience Research Communications

JF - Neuroscience Research Communications

IS - SUPPL. 1

ER -

New implications of memory mechanisms for Alzheimer's disease.

Abstract

Keywords

ASJC Scopus subject areas

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