New Trends in Nanoarchitectured SERS Substrates: Nanospaces, 2D Materials, and Organic Heterostructures

Olga Guselnikova*, Hyunsoo Lim*, Hyun Jong Kim, Sung Hyun Kim, Alina Gorbunova, Miharu Eguchi, Pavel Postnikov, Takuya Nakanishi, Toru Asahi, Jongbeom Na, Yusuke Yamauchi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


This article reviews recent fabrication methods for surface-enhanced Raman spectroscopy (SERS) substrates with a focus on advanced nanoarchitecture based on noble metals with special nanospaces (round tips, gaps, and porous spaces), nanolayered 2D materials, including hybridization with metallic nanostructures (NSs), and the contemporary repertoire of nanoarchitecturing with organic molecules. The use of SERS for multidisciplinary applications has been extensively investigated because the considerably enhanced signal intensity enables the detection of a very small number of molecules with molecular fingerprints. Nanoarchitecture strategies for the design of new NSs play a vital role in developing SERS substrates. In this review, recent achievements with respect to the special morphology of metallic NSs are discussed, and future directions are outlined for the development of available NSs with reproducible preparation and well-controlled nanoarchitecture. Nanolayered 2D materials are proposed for SERS applications as an alternative to the noble metals. The modern solutions to existing limitations for their applications are described together with the state-of-the-art in bio/environmental SERS sensing using 2D materials-based composites. To complement the existing toolbox of plasmonic inorganic NSs, hybridization with organic molecules is proposed to improve the stability of NSs and selectivity of SERS sensing by hybridizing with small or large organic molecules.

Original languageEnglish
Article number2107182
Issue number25
Publication statusPublished - 2022 Jun 23


  • 2D materials
  • SERS substrates
  • functionalization
  • nanogaps
  • nanoparticles
  • porous spaces
  • surface enhanced Raman spectroscopy

ASJC Scopus subject areas

  • Biotechnology
  • Chemistry(all)
  • Biomaterials
  • Materials Science(all)


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